PMID- 21771823 OWN - NLM STAT- MEDLINE DCOM- 20120118 LR - 20220317 IS - 1879-0844 (Electronic) IS - 1388-9842 (Linking) VI - 13 IP - 9 DP - 2011 Sep TI - The European Cardiac Resynchronization Therapy Survey: comparison of outcomes between de novo cardiac resynchronization therapy implantations and upgrades. PG - 974-83 LID - 10.1093/eurjhf/hfr085 [doi] AB - AIMS: Cardiac resynchronization therapy (CRT) is an effective treatment for a subset of patients with chronic heart failure. Data on the benefit of CRT in heart failure patients with previous right ventricular pacemakers or standard defibrillators are sparse. METHODS AND RESULTS: The European (HFA, Heart Failure Association/EHRA, European Heart Rhythm Association) CRT Survey enrolled patients from 141 centres in 13 countries in Europe collecting baseline demographic, echocardiographic, clinical, and implant data, with follow-up at approximately 1 year. The present analysis reports implantation data and 1 year outcomes regarding New York Heart Association (NYHA) class, global patient assessment, hospitalizations, complications, and mortality in patients undergoing de novo CRT implantations compared with those receiving an upgrade of a previously implanted device (pacemaker or implantable cardioverter-defibrillators). This analysis includes 2367 CRT implant procedures of which 692 (28%) were upgrades to CRT. Distribution of NYHA functional class and left ventricular function were similar between the groups. Procedural duration was also similar, although fluoroscopy time was shorter in the 'upgrades'. There was no difference in the frequency of peri-procedural complications. There were similar improvements in NYHA functional class and similar reduction in QRS duration, but more patients reported unchanged global assessment status in the upgraded group. Total and cause-specific mortality at 1 year was low and the same in both groups. CONCLUSIONS: More than one quarter of all CRT procedures are upgrades from existing systems, although this group has not been subject to randomized clinical trials. Our data suggest that there are no significant differences in clinical outcomes or complication rates between upgrades and de novo procedures. Clinical study no NCT 01185392. FAU - Bogale, Nigussie AU - Bogale N AD - Stavanger University Hospital, Stavanger and Institute of Medicine, University of Bergen, Bergen, Norway. nigussie.bogale@lyse.net FAU - Witte, Klaus AU - Witte K FAU - Priori, Silvia AU - Priori S FAU - Cleland, John AU - Cleland J FAU - Auricchio, Angelo AU - Auricchio A FAU - Gadler, Fredrik AU - Gadler F FAU - Gitt, Anselm AU - Gitt A FAU - Limbourg, Tobias AU - Limbourg T FAU - Linde, Cecilia AU - Linde C FAU - Dickstein, Kenneth AU - Dickstein K CN - Scientific Committee, National coordinators and the investigators LA - eng SI - ClinicalTrials.gov/NCT01185392 PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110719 PL - England TA - Eur J Heart Fail JT - European journal of heart failure JID - 100887595 SB - IM MH - Aged MH - Aged, 80 and over MH - *Cardiac Resynchronization Therapy MH - *Defibrillators, Implantable MH - Europe/epidemiology MH - Female MH - Heart Failure/*mortality/physiopathology/*therapy MH - Humans MH - Male MH - Middle Aged MH - Severity of Illness Index MH - Treatment Outcome FIR - Fruhwald, Friedrich IR - Fruhwald F FIR - Strohmer, Bernhard IR - Strohmer B FIR - Goethals, Marc IR - Goethals M FIR - Vijgen, Johan IR - Vijgen J FIR - Trochu, Jean Noel IR - Trochu JN FIR - Gras, Daniel IR - Gras D FIR - Kindermann, Michael IR - Kindermann M FIR - Stellbrink, Christoph IR - Stellbrink C FIR - McDonnald, Ken IR - McDonnald K FIR - Keane, David IR - Keane D FIR - Ben Gal, Tuvia IR - Ben Gal T FIR - Glikson, Michael IR - Glikson M FIR - Metra, Marco IR - Metra M FIR - Gasparini, Maurizio IR - Gasparini M FIR - Maass, Alexander IR - Maass A FIR - Jordaens, Luc IR - Jordaens L FIR - Alings, Marco IR - Alings M FIR - Larsen, Alf Inge IR - Larsen AI FIR - Faerestrand, Svein IR - Faerestrand S FIR - Delgado, Juan IR - Delgado J FIR - Mont, Lluis IR - Mont L FIR - Persson, Hans IR - Persson H FIR - Gadler, Fredrik IR - Gadler F FIR - Brunner-La Rocca, Hans Peter IR - Brunner-La Rocca HP FIR - Osswald, Stefan IR - Osswald S FIR - Squire, Ian IR - Squire I FIR - Morgan, John IR - Morgan J FIR - Dickstein, Kenneth IR - Dickstein K FIR - Priori, Silvia IR - Priori S FIR - Auricchio, Angelo IR - Auricchio A FIR - Bogale, Nigussie IR - Bogale N FIR - Brugada, Josep IR - Brugada J FIR - Cleland, John G F IR - Cleland JG FIR - Derumeaux, Genevieve IR - Derumeaux G FIR - Gitt, Anselm IR - Gitt A FIR - Gras, Daniel IR - Gras D FIR - Komajda, Michel IR - Komajda M FIR - Linde, Cecilia IR - Linde C FIR - Morgan, John IR - Morgan J FIR - van Veldhuisen, Dirk J IR - van Veldhuisen DJ EDAT- 2011/07/21 06:00 MHDA- 2012/01/19 06:00 CRDT- 2011/07/21 06:00 PHST- 2011/07/21 06:00 [entrez] PHST- 2011/07/21 06:00 [pubmed] PHST- 2012/01/19 06:00 [medline] AID - hfr085 [pii] AID - 10.1093/eurjhf/hfr085 [doi] PST - ppublish SO - Eur J Heart Fail. 2011 Sep;13(9):974-83. doi: 10.1093/eurjhf/hfr085. Epub 2011 Jul 19.