PMID- 21772323
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20211203
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Linking)
VI  - 12
IP  - 8
DP  - 2011 Jul 20
TI  - Fighting neurodegeneration with rapamycin: mechanistic insights.
PG  - 437-52
LID - 10.1038/nrn3068 [doi]
AB  - A growing number of studies point to rapamycin as a pharmacological compound that 
      is able to provide neuroprotection in several experimental models of 
      neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, 
      Huntington's disease and spinocerebellar ataxia type 3. In addition, rapamycin 
      exerts strong anti-ageing effects in several species, including mammals. By 
      inhibiting the activity of mammalian target of rapamycin (mTOR), rapamycin 
      influences a variety of essential cellular processes, such as cell growth and 
      proliferation, protein synthesis and autophagy. Here, we review the molecular 
      mechanisms underlying the neuroprotective effects of rapamycin and discuss the 
      therapeutic potential of this compound for neurodegenerative diseases.
FAU - Bove, Jordi
AU  - Bove J
AD  - Neurodegenerative Diseases Research Group, Vall d'Hebron Research 
      Institute-CIBERNED, 08035 Barcelona, Spain.
FAU - Martinez-Vicente, Marta
AU  - Martinez-Vicente M
FAU - Vila, Miquel
AU  - Vila M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110720
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Humans
MH  - Nerve Degeneration/*drug therapy/metabolism
MH  - Neurodegenerative Diseases/*drug therapy/metabolism
MH  - Signal Transduction/drug effects/physiology
MH  - Sirolimus/pharmacokinetics/*therapeutic use
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2011/07/21 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - nrn3068 [pii]
AID - 10.1038/nrn3068 [doi]
PST - epublish
SO  - Nat Rev Neurosci. 2011 Jul 20;12(8):437-52. doi: 10.1038/nrn3068.