PMID- 21772929
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220330
IS  - 1874-1924 (Electronic)
IS  - 1874-1924 (Linking)
VI  - 5
DP  - 2011
TI  - Relationship Between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical 
      Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease.
PG  - 110-6
LID - 10.2174/1874192401105010110 [doi]
AB  - BACKGROUND: Matrix metalloproteinases (MMPs) and Tissue Inhibitor of Matrix 
      Metalloproteinases (TIMPs) may be associated with atherogenesis and plaque 
      rupture. We evaluated the relationship between MMP-1, MMP-9, TIMP-1 and IL-6 
      levels and risk factors, presentation, extent and severity of atherosclerotic 
      coronary artery disease (CAD). METHODS: Consecutive patients who underwent 
      coronary angiography were randomly included. The serum concentrations of MMP-1, 
      MMP-9, TIMP-1 and IL-6 were analyzed with ELISA method in 134 patients. 
      Participants were divided into 5 groups; stable angina pectoris (SAP; n= 34), 
      unstable angina pectoris (USAP; n=29), non-ST elevation myocardial infarction 
      (NSTEMI; n=16), acute ST elevation myocardial infarction (STEMI; n=25) and 
      controls (n=30). Coronary angiographic Gensini score was calculated. RESULTS: 
      MMP-1 levels were higher in STEMI and NSTEMI groups compared with USAP, SAP and 
      control groups (STEMI vs USAP p=0.005; STEMI vs SAP p=0.001; STEMI vs control 
      p<0.001; NSTEMI vs USAP p=0.02; NSTEMI vs SAP p=0.027; NSTEMI vs control 
      p<0.001). In STEMI group, MMP-9 levels were higher than USAP and control groups 
      (p=0.002; p<0,001). TIMP-1 levels were not significantly different within all 5 
      groups. MMP-1 levels were found to be elevated in diabetic patients (p=0.020); 
      whereas MMP-9 levels were higher in smokers (p=0.043). Higher MMP-1, MMP-9 and 
      IL-6 levels were correlated with severe Left Anterior Descending artery (LAD) 
      stenosis and higher angiographic Gensini Score (for severe LAD stenosis; r = 
      0.671, 0.363, 0.509 p<0.001; for Gensini score; r = 0.717, 0.371, 0.578 p<0.001). 
      CONCLUSIONS: Serum levels of MMP-1, MMP-9, and IL-6 are elevated in patients with 
      CAD; more so in acute coronary syndromes. MMP-1, MMP-9 and IL-6 are associated 
      with more extensive and severe CAD (as represented by Gensini score).
FAU - Tanindi, Asli
AU  - Tanindi A
AD  - Gazi University Faculty of Medicine, Department of Cardiology, Turkey.
FAU - Sahinarslan, Asife
AU  - Sahinarslan A
FAU - Elbeg, Sehri
AU  - Elbeg S
FAU - Cemri, Mustafa
AU  - Cemri M
LA  - eng
PT  - Journal Article
DEP - 20110513
PL  - United Arab Emirates
TA  - Open Cardiovasc Med J
JT  - The open cardiovascular medicine journal
JID - 101480504
PMC - PMC3136999
OTO - NOTNLM
OT  - Gensini score.
OT  - Interleukin-6
OT  - Matrix metalloproteinase
OT  - coronary artery disease
EDAT- 2011/07/21 06:00
MHDA- 2011/07/21 06:01
PMCR- 2011/01/01
CRDT- 2011/07/21 06:00
PHST- 2011/04/04 00:00 [received]
PHST- 2011/04/12 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/07/21 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - TOCMJ-5-110 [pii]
AID - 10.2174/1874192401105010110 [doi]
PST - ppublish
SO  - Open Cardiovasc Med J. 2011;5:110-6. doi: 10.2174/1874192401105010110. Epub 2011 
      May 13.