PMID- 21774806
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20220318
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 9
DP  - 2011 Jul 20
TI  - Serum cytokine profiles in healthy young and elderly population assessed using 
      multiplexed bead-based immunoassays.
PG  - 113
LID - 10.1186/1479-5876-9-113 [doi]
AB  - BACKGROUND: Lipid metabolites and cytokines, including chemokines and growth 
      factors, are the key regulators of immune cell function and differentiation, and 
      thus, dysregulation of these regulators is associated with various human 
      diseases. However, previous studies demonstrating a positive correlation of 
      cytokine levels with aging may have been influenced by various environmental 
      factors and underlying diseases. Also, data regarding cytokine profiling in the 
      elderly are limited to a small subset of cytokines. METHODS: We compared the 
      profiles of 22 cytokines, including chemokines and growth factors, in a 
      case-controlled study group of a gender-matched, healthy cohort of 55 patients 
      over the age of 65 and 55 patients under the age of 45. Assessment of serum 
      cytokine concentrations was performed using commercially-available multiplex 
      bead-based sandwich immunoassays. RESULTS: Soluble CD40 ligand (sCD40L) and 
      transforming growth factor alpha (TGF-alpha) levels were significantly higher in the 
      elderly patients, whereas granulocyte colony-stimulating factor (G-CSF), 
      granulocyte-monocyte colony-stimulating factor (GM-CSF), and monocyte 
      chemoattractant protein-1 (MCP-1) levels were significantly lower in the elderly 
      patients. The partial correlation analysis demonstrating the correlation between 
      cytokine levels when controlled for gender, systolic blood pressure, total 
      cholesterol, HDL cholesterol, triglyceride, and serum creatinine levels further 
      demonstrated that G-CSF, GM-CSF, and MCP-1 had significant negative correlations 
      with age, whereas sCD40L and TGF-alpha had significant positive correlations. 
      CONCLUSIONS: Future studies will focus on examining the significance of these 
      age-related changes in circulating cytokines and other biological markers and 
      their potential contribution to the development of different age-associated 
      diseases.
FAU - Kim, Hyun Ok
AU  - Kim HO
AD  - Department of Laboratory Medicine and Cell Therapy Center, Yonsei University 
      College of Medicine, Seoul 120-752, Republic of Korea.
FAU - Kim, Han-Soo
AU  - Kim HS
FAU - Youn, Jong-Chan
AU  - Youn JC
FAU - Shin, Eui-Cheol
AU  - Shin EC
FAU - Park, Sungha
AU  - Park S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*blood
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/physiology
MH  - Body Mass Index
MH  - Chemokines/blood
MH  - Cholesterol/blood
MH  - Creatinine/blood
MH  - Cytokines/*blood
MH  - Female
MH  - *Health
MH  - Humans
MH  - Immunoassay/*methods
MH  - Intercellular Signaling Peptides and Proteins/blood
MH  - Male
MH  - *Microspheres
MH  - Smoking/blood
MH  - Triglycerides/blood
PMC - PMC3146842
EDAT- 2011/07/22 06:00
MHDA- 2011/12/13 00:00
PMCR- 2011/07/20
CRDT- 2011/07/22 06:00
PHST- 2011/06/01 00:00 [received]
PHST- 2011/07/20 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2011/07/20 00:00 [pmc-release]
AID - 1479-5876-9-113 [pii]
AID - 10.1186/1479-5876-9-113 [doi]
PST - epublish
SO  - J Transl Med. 2011 Jul 20;9:113. doi: 10.1186/1479-5876-9-113.