PMID- 21775452
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20211231
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 85
IP  - 19
DP  - 2011 Oct
TI  - CD11c controls herpes simplex virus 1 responses to limit virus replication during 
      primary infection.
PG  - 9945-55
LID - 10.1128/JVI.05208-11 [doi]
AB  - CD11c is expressed on the surface of dendritic cells (DCs) and is one of the main 
      markers for identification of DCs. DCs are the effectors of central innate immune 
      responses, but they also affect acquired immune responses to infection. However, 
      how DCs influence the efficacy of adaptive immunity is poorly understood. Here, 
      we show that CD11c(+) DCs negatively orchestrate both adaptive and innate 
      immunity against herpes simplex virus type 1 (HSV-1) ocular infection. The 
      effectiveness and quantity of virus-specific CD8(+) T cell responses are 
      increased in CD11c-deficient animals. In addition, the levels of CD83, CD11b, 
      alpha interferon (IFN-alpha), and IFN-beta, but not IFN-gamma, were significantly increased 
      in CD11c-deficient animals. Higher levels of IFN-alpha, IFN-beta, and CD8(+) T cells in 
      the CD11c-deficient mice may have contributed to lower virus replication in the 
      eye and trigeminal ganglia (TG) during the early period of infection than in 
      wild-type mice. However, the absence of CD11c did not influence survival, 
      severity of eye disease, or latency. Our studies provide for the first time 
      evidence that CD11c expression may abrogate the ability to reduce primary virus 
      replication in the eye and TG via higher activities of type 1 interferon and 
      CD8(+) T cell responses.
FAU - Allen, Sariah J
AU  - Allen SJ
AD  - Center for Neurobiology and Vaccine Development-SSB3, Regenerative Medicine 
      Institute, Los Angeles, CA 90048, USA.
FAU - Mott, Kevin R
AU  - Mott KR
FAU - Chentoufi, Aziz A
AU  - Chentoufi AA
FAU - BenMohamed, Lbachir
AU  - BenMohamed L
FAU - Wechsler, Steven L
AU  - Wechsler SL
FAU - Ballantyne, Christie M
AU  - Ballantyne CM
FAU - Ghiasi, Homayon
AU  - Ghiasi H
LA  - eng
GR  - R01 EY013191/EY/NEI NIH HHS/United States
GR  - EY15557/EY/NEI NIH HHS/United States
GR  - EY13615/EY/NEI NIH HHS/United States
GR  - T32 AI089553/AI/NIAID NIH HHS/United States
GR  - R01 EY014966/EY/NEI NIH HHS/United States
GR  - EY013191/EY/NEI NIH HHS/United States
GR  - T32-AI-89553/AI/NIAID NIH HHS/United States
GR  - R01 EY013615/EY/NEI NIH HHS/United States
GR  - R01 EY015557/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110720
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (CD11c Antigen)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - CD11c Antigen/immunology/*metabolism
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Disease Models, Animal
MH  - Eye/immunology/virology
MH  - Eye Infections/immunology/pathology/virology
MH  - Herpes Simplex/immunology/pathology/virology
MH  - Herpesvirus 1, Human/*immunology/*pathogenicity
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Rodent Diseases/immunology/pathology/virology
MH  - Survival Analysis
MH  - Trigeminal Ganglion/immunology/virology
MH  - *Virus Replication
PMC - PMC3196403
EDAT- 2011/07/22 06:00
MHDA- 2011/11/01 06:00
PMCR- 2012/04/01
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - JVI.05208-11 [pii]
AID - 5208-11 [pii]
AID - 10.1128/JVI.05208-11 [doi]
PST - ppublish
SO  - J Virol. 2011 Oct;85(19):9945-55. doi: 10.1128/JVI.05208-11. Epub 2011 Jul 20.