PMID- 21775536
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20211020
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Print)
IS  - 0095-1137 (Linking)
VI  - 49
IP  - 9
DP  - 2011 Sep
TI  - Epidemiology and evolutionary characteristics of the porcine reproductive and 
      respiratory syndrome virus in China between 2006 and 2010.
PG  - 3175-83
LID - 10.1128/JCM.00234-11 [doi]
AB  - In 2006, an emerging highly pathogenic strain of porcine reproductive and 
      respiratory syndrome virus (PRRSV), which causes continuous high fever and a high 
      proportion of deaths in vaccinated pigs of all ages, broke out in mainland China 
      and spread rapidly to neighboring countries. To examine the epidemiology and 
      evolutionary characteristics of Chinese PRRSV after the 2006 outbreak, we tested 
      2,981 clinical samples collected from 2006 to 2010 in China, determined 153 Nsp2 
      sequences and 249 ORF5 sequences, and analyzed the epidemiology and genetic 
      diversity of Chinese PRRSV. Our results showed that the percentage of 
      PRRSV-positive specimens collected from sick pigs averaged 60.85% in the past 5 
      years and that the highly pathogenic PRRSV has become the dominant strain in 
      China. Furthermore, a reemerging strain which apparently evolved from the highly 
      pathogenic PRRSV strain in 2006 appeared to be widely prevalent in China from 
      2009 onwards. Sequence analyses revealed that the hypervariable region of Nsp2 in 
      most of the isolates contained a discontinuous deletion equivalent to 30 amino 
      acids, along with other types of deletions. Extensive amino acid substitutions in 
      the GP5 sequence translated from ORF5 were found, particularly in the potential 
      neutralization epitope and the N-glycosylation sites. Our results suggest that 
      Chinese PRRSV has undergone rapid evolution and can circumvent immune responses 
      induced by currently used vaccines. Information from this study will help in 
      understanding the evolutionary characteristics of Chinese PRRSV and assist 
      ongoing efforts to develop and use PRRSV vaccines in the future.
FAU - Li, Bin
AU  - Li B
AD  - Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, 
      Nanjing 210014, China.
FAU - Fang, Liurong
AU  - Fang L
FAU - Guo, Xueliang
AU  - Guo X
FAU - Gao, Jianfeng
AU  - Gao J
FAU - Song, Tao
AU  - Song T
FAU - Bi, Jing
AU  - Bi J
FAU - He, Kongwang
AU  - He K
FAU - Chen, Huanchun
AU  - Chen H
FAU - Xiao, Shaobo
AU  - Xiao S
LA  - eng
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PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Substitution
MH  - Animals
MH  - China/epidemiology
MH  - *Disease Outbreaks
MH  - *Evolution, Molecular
MH  - Molecular Epidemiology
MH  - Molecular Sequence Data
MH  - Polymorphism, Genetic
MH  - Porcine Reproductive and Respiratory Syndrome/*epidemiology/*virology
MH  - Porcine respiratory and reproductive syndrome 
      virus/*classification/*genetics/isolation & purification
MH  - RNA, Viral/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Deletion
MH  - Swine
MH  - Viral Proteins/genetics
PMC - PMC3165578
EDAT- 2011/07/22 06:00
MHDA- 2011/12/17 06:00
PMCR- 2012/03/01
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - JCM.00234-11 [pii]
AID - 0234-11 [pii]
AID - 10.1128/JCM.00234-11 [doi]
PST - ppublish
SO  - J Clin Microbiol. 2011 Sep;49(9):3175-83. doi: 10.1128/JCM.00234-11. Epub 2011 
      Jul 20.