PMID- 21776281
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-9678 (Electronic)
IS  - 1687-966X (Print)
VI  - 2011
DP  - 2011
TI  - Dendritic cells in cord blood transplantation: a review.
PG  - 539896
LID - 10.4061/2011/539896 [doi]
LID - 539896
AB  - Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells 
      derived from hematopoietic progenitors that bridge the transition between the 
      innate and adaptive immune responses, while maintaining self-tolerance and 
      Th1/Th2 homeostasis, by priming other cells in either an immunogenic or 
      tolerogenic direction. Through their role in both innate and adaptive immunity, 
      DCs play a major part in transplant engraftment and rejection and in 
      graft-versus-host disease (GvHD). Preferentially tolerogenic or immunogenic DC 
      subtypes offer targets for immunotherapy, to optimize transplant success rates 
      and prolong disease-free and overall survival. Cord blood DCs are immature and 
      preferentially tolerogenic, due to maternal-fetal tolerance, leading to better 
      graft acceptance and immune reconstitution and explaining the lower incidence and 
      severity of GvHD in CB transplantation, despite donor-host mismatching. 
      Manipulation of DC maturation and cell loading with tumor-antigens can direct 
      antitumor immunity and target minimal residual disease, as demonstrated for acute 
      myeloid leukemia, optimizing the graft-versus-leukemia effect.
FAU - Pereira, Marta Isabel
AU  - Pereira MI
AD  - Clinical Hematology Department, Coimbra University Hospitals, Coimbra, Portugal.
FAU - Paiva, Artur
AU  - Paiva A
LA  - eng
PT  - Journal Article
DEP - 20110616
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3137980
EDAT- 2011/07/22 06:00
MHDA- 2011/07/22 06:01
PMCR- 2011/06/16
CRDT- 2011/07/22 06:00
PHST- 2011/01/16 00:00 [received]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/07/22 06:01 [medline]
PHST- 2011/06/16 00:00 [pmc-release]
AID - 10.4061/2011/539896 [doi]
PST - ppublish
SO  - Stem Cells Int. 2011;2011:539896. doi: 10.4061/2011/539896. Epub 2011 Jun 16.