PMID- 21777196
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20190911
IS  - 1873-5592 (Electronic)
IS  - 1389-4501 (Linking)
VI  - 12
IP  - 14
DP  - 2011 Dec
TI  - Heat shock proteins: a potential anticancer target.
PG  - 2001-8
AB  - Heat shock proteins (Hsp) are highly conserved proteins and their expression is 
      dependent on the level of various cellular stresses. Hsp work as a molecular 
      chaperon for several cellular proteins and have cytoprotective roles. Their 
      function is essential for normal cell viability and growth. Hsp90 interacts with 
      proteins mediating cell signaling involved in essential processes such as 
      proliferation, cell cycle control, angiogenesis and apoptosis. The naturally 
      occurring Hsp90 inhibitor geldanamycin (GA) was the first to demonstrate 
      anticancer activity but its significant toxicity profile in pre-clinical models 
      precluded its clinical development. Subsequent, several Hsp90 inhibitors have 
      been developed and underwent clinical development with favorable safety profiles. 
      Several initial clinical studies have shown promising anticancer activity of 
      Hsp90 inhibitors mainly in breast cancer, non small cell lung carcinoma (NSCLC), 
      gastrointestinal stromal tumors (GIST) and various hematological malignancies. 
      The universal involvement of Hsp90 in multiple oncogenic processes makes Hsp90 
      inhibitors ideal compounds to be explored as a single agent or in combination 
      with other anticancer therapies.
FAU - Sankhala, Kamalesh K
AU  - Sankhala KK
AD  - Institute for Drug Development at CTRC, The University of Texas Health Science 
      Center, San Antonio, TX, USA. Sankhala@uthscsa.edu
FAU - Mita, Monica M
AU  - Mita MM
FAU - Mita, Alain C
AU  - Mita AC
FAU - Takimoto, Chris H
AU  - Takimoto CH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HSP90 Heat-Shock Proteins)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - HSP90 Heat-Shock Proteins/*antagonists & inhibitors/chemistry/physiology
MH  - Humans
MH  - Neoplasm Invasiveness
MH  - Neoplasms/blood supply/drug therapy/etiology
EDAT- 2011/07/23 06:00
MHDA- 2012/06/12 06:00
CRDT- 2011/07/23 06:00
PHST- 2010/07/14 00:00 [received]
PHST- 2010/09/23 00:00 [revised]
PHST- 2010/10/01 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - BSP/CDT/E-Pub/00334 [pii]
AID - 10.2174/138945011798829339 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2011 Dec;12(14):2001-8. doi: 10.2174/138945011798829339.