PMID- 21777341
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20161020
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Feb
TI  - Low levels of adherence with proton pump inhibitor therapy contribute to 
      therapeutic failure in gastroesophageal reflux disease.
PG  - 107-13
LID - 10.1111/j.1442-2050.2011.01227.x [doi]
AB  - To assess adherence to proton pump inhibitor (PPI) treatment and associated 
      variables in patients with gastroesophageal reflux disease (GERD). 
      Cross-sectional and prospective comprising 240 consecutive adult patients, 
      diagnosed with GERD for whom continuous use of standard or double dose of 
      omeprazole had been prescribed. Patients were ranked as ne-GERD (162: 67.5%) or 
      e-GERD classified according to the Los Angeles classification as A (48:20.0%), B 
      (21:8.6%), C (1:0.5%), D (1:0.5%), and Barrett's esophagus (7:2.9%). The Morisky 
      questionnaire was applied to assess adherence to therapy and a GERD questionnaire 
      to assess symptoms and their impact. Adherence was correlated with demographics, 
      cotherapies, comorbidities, treatment duration, symptoms scores, endoscopic 
      findings, and patient awareness of their disease. 126 patients (52.5%) exhibited 
      high level of adherence and 114 (47.5%) low level. Youngers (P= 0.002) or married 
      (O.R. 2.41, P= 0.03 vs. widowers) patients had lower levels of adherence; 
      symptomatic patients exhibited lower adherence (P= 0.02). All other variables 
      studied had no influence on adherence. Patients with GERD attending a tertiary 
      referral hospital in Sao Paulo exhibited a high rate of low adherence to the 
      prescribed PPI therapy that may play a role in the therapy failure. Age <60 
      years, marital status and being symptomatic were risk factors for low adherence.
CI  - (c) 2011 Copyright the Authors. Journal compilation (c) 2011, Wiley Periodicals, Inc. 
      and the International Society for Diseases of the Esophagus.
FAU - Dal-Paz, K
AU  - Dal-Paz K
AD  - Department of Gastroenterology, University of Sao Paulo, School of Medicine, Sao 
      Paulo, Brazil.
FAU - Moraes-Filho, J P
AU  - Moraes-Filho JP
FAU - Navarro-Rodriguez, T
AU  - Navarro-Rodriguez T
FAU - Eisig, J N
AU  - Eisig JN
FAU - Barbuti, R
AU  - Barbuti R
FAU - Quigley, E M M
AU  - Quigley EM
LA  - eng
PT  - Journal Article
DEP - 20110721
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Omeprazole/*therapeutic use
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2011/07/23 06:00
MHDA- 2013/03/15 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1111/j.1442-2050.2011.01227.x [doi]
PST - ppublish
SO  - Dis Esophagus. 2012 Feb;25(2):107-13. doi: 10.1111/j.1442-2050.2011.01227.x. Epub 
      2011 Jul 21.