PMID- 21777528
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110722
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 21
IP  - 7
DP  - 2011 Jul
TI  - Factors predicting the recurrence of spontaneous bacterial peritonitis in 
      patients with cirrhosis.
PG  - 407-10
AB  - OBJECTIVE: To evaluate the frequency of recurrence of spontaneous bacterial 
      peritonitis (SBP) in patients with end stage liver disease and the factors 
      responsible for it. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: 
      The Aga Khan University Hospital, Karachi, from November 2008 till November 2009. 
      METHODOLOGY: Patients with cirrhosis who were admitted at AKUH with diagnosis of 
      SBP during the study period were included. Any episode of SBP after resolution of 
      the first index case of SBP within one year was considered as recurrence. 
      RESULTS: Out of 238 cirrhotic patients, 157 (66%) had single, while 81 (34%) had 
      recurrent episodes of SBP. History of using proton pump inhibitors (PPI) and 
      diuretics was found in 113 (47.5%) and 139 (58.4%) patients respectively. Only 58 
      24.4%) patients were on prophylactic antibiotic therapy. Univariate analysis 
      revealed that the female gender (52%), and presence of porto-systemic 
      encephalopathy (PSE, 31%) were statistically significant (p=0.03) among those who 
      had recurrent SBP. On multivariate analysis bilirubin level of > 1.0 mg (OR=7.03; 
      95%CI=1.55-32), protective factor of hepatitis B (OR 0.31; 95%CI=0.13-0.70) and 
      presence of urinary tract infection (UTI) (OR=2.24; 95%CI=0.99-5.09) were 
      significant in patients with recurrent SBP. CONCLUSION: Recurrent SBP was noticed 
      in 34% patients. Serum bilirubin level of > 1.0 mg, protective factor of HBV and 
      presence of UTI were significant factors present in patients with recurrent SBP.
FAU - Jamil, Sajjad
AU  - Jamil S
AD  - Department of Medicine, The Aga Khan University Hospital, Karachi.
FAU - Ahmed, Shahid
AU  - Ahmed S
FAU - Memon, Adil
AU  - Memon A
FAU - Masood, Sara
AU  - Masood S
FAU - Ali Shah, Syed Hasnain
AU  - Ali Shah SH
FAU - Hamid, Saeed Sadiq
AU  - Hamid SS
FAU - Wasim Jafri, S M
AU  - Wasim Jafri SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
SB  - IM
MH  - Adult
MH  - Bacterial Infections/complications/diagnosis/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Liver Cirrhosis/*complications/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Pakistan/epidemiology
MH  - Peritonitis/complications/diagnosis/*epidemiology
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Factors
EDAT- 2011/07/23 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/07/23 06:00
PHST- 2010/11/27 00:00 [received]
PHST- 2011/05/16 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 040579197 [pii]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2011 Jul;21(7):407-10.