PMID- 2177854
OWN - NLM
STAT- MEDLINE
DCOM- 19910311
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 52
IP  - 5
DP  - 1990 Nov
TI  - Induction by tumor necrosis factor-alpha of rapid release of immunoreactive and 
      bioactive luteinizing hormone from rat pituitary cells in vitro.
PG  - 468-72
AB  - Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes and 
      other immune cells. This paper reports studies on the effects of TNF-alpha on the 
      releases of pituitary hormones such as luteinizing hormone (LH), 
      follicle-stimulating hormone, prolactin (PRL) and adrenocorticotropic hormone 
      (ACTH). The addition of recombinant human TNF-alpha (rTNF-alpha) to cultures of 
      pituitary cells resulted in significantly increased releases of gonadotropins, 
      PRL, and ACTH for up to 30 min, but not later. rTNF-alpha, like GnRH, also 
      stimulated the release of bioactive LH. In addition, rTNF-alpha induced 
      production of an interleukin-6 (IL-6)-like molecule by pituitary cells. As IL-6 
      induces the releases of multiple hormones from pituitary cells, our data suggest 
      that rTNF-alpha may stimulate the releases of multiple pituitary hormones through 
      IL-6 production as well as by its direct action on pituitary cells.
FAU - Yamaguchi, M
AU  - Yamaguchi M
AD  - Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
FAU - Sakata, M
AU  - Sakata M
FAU - Matsuzaki, N
AU  - Matsuzaki N
FAU - Koike, K
AU  - Koike K
FAU - Miyake, A
AU  - Miyake A
FAU - Tanizawa, O
AU  - Tanizawa O
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Interleukin-6)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/metabolism
MH  - Animals
MH  - Biological Assay
MH  - Cells, Cultured
MH  - Female
MH  - Follicle Stimulating Hormone/metabolism
MH  - Interleukin-6/analysis
MH  - Luteinizing Hormone/*metabolism
MH  - Pituitary Gland, Anterior/*drug effects/metabolism
MH  - Prolactin/metabolism
MH  - Radioimmunoassay
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Recombinant Proteins/pharmacology
MH  - Secretory Rate/drug effects
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
AID - 10.1159/000125630 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1990 Nov;52(5):468-72. doi: 10.1159/000125630.