PMID- 21779934
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150724
LR  - 20211020
IS  - 1936-0533 (Print)
IS  - 1936-0533 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Jun
TI  - Host genetic variants and hepatitis B virologic features in HBeAg-negative 
      hepatitis B carriers with long-term biochemical remission.
PG  - 598-605
LID - 10.1007/s12072-011-9297-4 [doi]
AB  - PURPOSE: A significant portion of HBeAg-negative chronic hepatitis B patients 
      have persistently normal serum alanine aminotransferase levels (PNALT). We thus 
      investigated host genetic variants and virological features in HBeAg-negative 
      hepatitis B carriers. METHODS: Baseline clinical and virological features of 133 
      HBeAg-negative hepatitis B carriers (77 with PNALT and 56 with chronic hepatitis 
      activity) with follow-up for more than 5 years were investigated. Three single 
      nucleotide polymorphisms (SNPs) located within or around human leukocyte antigen 
      (HLA)-DPA1, HLA-DPB1, and interleukin (IL) 28B loci were genotyped. RESULTS: The 
      genotype frequencies of these SNPs were comparable between hepatitis B carriers 
      with PNALT and those with chronic hepatitis. Compared with hepatitis B carriers 
      with PNALT, those with chronic hepatitis had significantly higher baseline serum 
      HBV-DNA levels (4.96 vs. 4.04 log10 IU/ml, P = 0.001). Baseline serum HBV-DNA 
      level > 2000 IU/ml (OR, 8.42; 95% CI, 2.74-25.90, P < 0.001) were the only 
      independent factor associated with chronic hepatitis activity. Changes of serum 
      HBV-DNA in 30 hepatitis B carriers with PNALT had showed a significant reduction 
      of viral load from baseline to last visit (mean difference of paired HBV-DNA 
      levels: -0.78 log10 IU/ml, 95% CI: -1.57 to -0.013, P = 0.047). In contrast, no 
      significant reduction of viral load was found in 28 patients with chronic 
      hepatitis. CONCLUSIONS: The results indicate that lower baseline serum HBV-DNA 
      level and viral load reduction over time are associated with long-term 
      biochemical remission in HBeAg-negative hepatitis B carriers.
FAU - Lin, Chih-Lin
AU  - Lin CL
AD  - Department of Gastroenterology, Taipei City Hospital, Ren-Ai branch, Taipei, 
      Taiwan.
AD  - Department of Psychology, National Chengchi University, Taipei, Taiwan.
FAU - Tseng, Tai-Chung
AU  - Tseng TC
AD  - Division of Hepatogastroenterology, Department of Internal Medicine, Buddhist Tzu 
      Chi General Hospital, Taipei Branch, Taipei, Taiwan.
FAU - Su, Tung-Hung
AU  - Su TH
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Liu, Chun-Jen
AU  - Liu CJ
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - Graduate Institute of Clinical Medicine, National Taiwan University College of 
      Medicine, 1 Chang-Te St, Taipei, 10002, Taiwan.
AD  - Hepatitis Research Center, National Taiwan University College of Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chen, Pei-Jer
AU  - Chen PJ
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - Graduate Institute of Clinical Medicine, National Taiwan University College of 
      Medicine, 1 Chang-Te St, Taipei, 10002, Taiwan.
FAU - Lai, Ming-Yang
AU  - Lai MY
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - Graduate Institute of Clinical Medicine, National Taiwan University College of 
      Medicine, 1 Chang-Te St, Taipei, 10002, Taiwan.
FAU - Chen, Ding-Shinn
AU  - Chen DS
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Kao, Jia-Horng
AU  - Kao JH
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan. kaojh@ntu.edu.tw.
AD  - Graduate Institute of Clinical Medicine, National Taiwan University College of 
      Medicine, 1 Chang-Te St, Taipei, 10002, Taiwan. kaojh@ntu.edu.tw.
AD  - Hepatitis Research Center, National Taiwan University College of Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan. kaojh@ntu.edu.tw.
AD  - Department of Medical Research, National Taiwan University College of Medicine, 
      National Taiwan University Hospital, Taipei, Taiwan. kaojh@ntu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20110721
PL  - United States
TA  - Hepatol Int
JT  - Hepatology international
JID - 101304009
OTO - NOTNLM
OT  - Alanine aminotransferase
OT  - HBV-DNA
OT  - HBeAg-negative carrier
OT  - Hepatitis B virus
OT  - Host genetic variants
EDAT- 2011/07/23 06:00
MHDA- 2011/07/23 06:01
CRDT- 2011/07/23 06:00
PHST- 2011/02/22 00:00 [received]
PHST- 2011/06/24 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/07/23 06:01 [medline]
AID - 10.1007/s12072-011-9297-4 [pii]
AID - 10.1007/s12072-011-9297-4 [doi]
PST - ppublish
SO  - Hepatol Int. 2012 Jun;6(3):598-605. doi: 10.1007/s12072-011-9297-4. Epub 2011 Jul 
      21.