PMID- 21781174
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110916
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 22
IP  - 6
DP  - 2011 Sep
TI  - Maternal depression related to infant's wheezing.
PG  - 608-13
LID - 10.1111/j.1399-3038.2011.01155.x [doi]
AB  - OBJECTIVE: To assess whether maternal psychological status is related to infant's 
      wheezing. STUDY DESIGN: In a case-control study conducted in Paris in cases aged 
      less than 36 months suffering from wheezing and matched healthy controls, mothers 
      filled a standardized questionnaire on child's health and the State Trait Anxiety 
      Inventory form Y-B and the Beck Depression Inventory short form. Cases underwent 
      also routine clinical and biological assessments. The statistical analysis used 
      the propensity score analysis to control for selection bias. RESULTS: Hundred and 
      thirty-eight wheezers and hundred and nine controls participated in the study. 
      After adjustment for confounders, maternal depressive symptoms at the period of 
      the survey according to the Beck Inventory were more significantly found in the 
      cases than in others (p < 0.01). A trend was found for maternal depression during 
      pregnancy. Among the cases, 10.6% suffered from severe asthma, 84.8% took inhaled 
      corticosteroids (ICs), 17.4% had positive specific immunoglobulin E (IgE) to 
      allergens and 11.5% hypereosinophilia. The more the mother was depressed 
      according to the Beck Inventory, the more the infant's asthma was severe (OR = 
      4.25, 95% CI: 1.14, 15.9 between severe infant's wheezing and severe maternal 
      depression). No relationship was observed between mother's depressive symptoms 
      and ICs taken by the infant, allergic sensitization or eosinophilia. CONCLUSION: 
      Our findings support the hypothesis of a link between maternal depression and 
      infant's wheezing and its severity early in life independent of allergic status. 
      Consequences of our study include the need to assess depressive symptoms in 
      mothers of infants with asthma.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Lefevre, Francoise
AU  - Lefevre F
AD  - Centre de l'Asthme et des Allergies, Groupe Hospitalier Trousseau-La Roche Guyon, 
      Assistance Publique-Hopitaux de Paris, Universite Pierre et Marie Curie-Paris6, 
      Paris, France.
FAU - Moreau, David
AU  - Moreau D
FAU - Semon, Elodie
AU  - Semon E
FAU - Kalaboka, Sofia
AU  - Kalaboka S
FAU - Annesi-Maesano, Isabella
AU  - Annesi-Maesano I
FAU - Just, Jocelyne
AU  - Just J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Asthma/epidemiology/etiology
MH  - Case-Control Studies
MH  - Depression/*complications
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Mothers/*psychology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*psychology
MH  - Respiratory Sounds/*etiology
EDAT- 2011/07/26 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1111/j.1399-3038.2011.01155.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2011 Sep;22(6):608-13. doi: 
      10.1111/j.1399-3038.2011.01155.x. Epub 2011 Apr 5.