PMID- 21781698
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20191112
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 2
IP  - 1
DP  - 1996 Aug 15
TI  - Toxicity of amphotericin B to analbuminemic rats.
PG  - 31-4
AB  - Nagase analbuminemic rats (NAR), a strain derived from Sprague Dawley rats (SDR), 
      are suitable to determine the in vivo effect of hyperlipidemia and analbuminemia 
      on the toxicity of the antifungal agent amphotericin B (AB). Cholesterol content 
      was increased in all plasma lipoprotein fractions when SDR serum was compared 
      with NAR serum. Incubation of AB with plasma from animals of both strains and 
      further isolation of plasma lipoprotein by ultracentrifugation, showed that, 
      while in SDR approximately 40% of the injected AB was in the lipoprotein 
      fraction, in NAR almost all (approximately 80%) AB was associated with 
      lipoproteins, especially in the low density lipoprotein fraction. AB 
      spectrophotometry showed differences in the extent of AB aggregation between SDR 
      and NAR plasma fractions. The lack of albumin results in aggregation of the AB 
      present in the infranatant fraction. In vivo, a strong reduction in lethality was 
      observed for NAR when compared to SDR (LD 50% of 6.4 and 1.9 mg/kg respectively). 
      The preferential distribution of AB in the plasma lipoprotein fraction seems to 
      affect pharmacological parameters, with a consequent reduction of toxicity.
FAU - Marzzullo, L
AU  - Marzzullo L
AD  - Department of Clinical Chemistry, Faculdade de Ciencias Farmaceuticas, 
      Universidade de Sao Paulo, S.P., CEP 05599-970, Sao Paulo, Brazil.
FAU - Oliveira, E P
AU  - Oliveira EP
FAU - Souza, L C
AU  - Souza LC
FAU - Campa, A
AU  - Campa A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 1996/08/15 00:00
MHDA- 1996/08/15 00:01
CRDT- 2011/07/26 06:00
PHST- 1995/12/07 00:00 [received]
PHST- 1996/04/26 00:00 [revised]
PHST- 1996/04/29 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 1996/08/15 00:00 [pubmed]
PHST- 1996/08/15 00:01 [medline]
AID - 1382-6689(96)00026-9 [pii]
AID - 10.1016/1382-6689(96)00026-9 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 1996 Aug 15;2(1):31-4. doi: 
      10.1016/1382-6689(96)00026-9.