PMID- 21782419
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20131121
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 48
IP  - 7
DP  - 2012 May
TI  - Improving cachectic symptoms and immune strength of tumour-bearing mice in 
      chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang.
PG  - 1074-84
LID - 10.1016/j.ejca.2011.06.048 [doi]
AB  - BACKGROUND: Cancer cachexia is characterised by the loss of body mass and 
      directly compromises immune response and the quality of life of cancer patients. 
      In the present study, we set out to investigate the role of Chinese herbs as 
      anticancer medicines and/or chemotherapeutic adjuvants to increase therapeutic 
      efficacy and/or ameliorate given side-effects in animal model. METHODS: Twelve 
      kinds of herbs were chosen from the ingredients of major Chinese herbal 
      medicines, and their effects on the antioxidant activity were investigated. To 
      obtain the anticancer effects of 5-fluorouracil (5-FU) when consumed with minimal 
      side-effects, we investigated the combination effect of Scutellaria baicalensis 
      and Qing-Shu-Yi-Qi-Tang that may enhance the anticancer activity of 5-FU on 
      subcutaneous tumour growth in C57BL/6 mice challenged with Lewis lung carcinoma 
      cells. RESULTS: Qing-Shu-Yi-Qi-Tang, a multiple-component herbal extract, was 
      shown to have high anti-oxidation activity, while S. baicalensis (Chinese 
      skullcap) was demonstrated to have high tumour-growth inhibition activity. Thus, 
      S. baicalensis and Qing-Shu-Yi-Qi-Tang were evaluated for their combinaton 
      effects on the cancer-induced cachectic murine upon receiving 5-FU chemotherapy. 
      As a result, tumour masses and losses of carcass and/or gastrocnemius muscle were 
      found to be significantly decreased. This combination otherwise increased both 
      Th1/Th2 ratio and NK cytotoxicity. In the mice receiving with or without 5-FU, 
      the serum levels of monocyte chemoattractant protein-1 (MCP-1) increased by all 
      means but otherwise decreased when the herbal combination was administrated. 
      Additionally, the expressions of nuclear factor-kappa B (NF-kappaB) and muscle RING 
      finger protein-1 (MuRF-1) decreased in the gastrocnemius muscle when the herbal 
      combination was applied. CONCLUSION: Our results revealed that the combination of 
      S. baicalensis and Qing-Shu-Yi-Qi-Tang is able to ameliorate cachectic symptoms 
      and positively stimulate anti-tumour immunity while undergoing chemotherapy in 
      animal model.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Wang, Hang
AU  - Wang H
AD  - Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan. 
      sandy72066@hotmail.com
FAU - Chan, Yi-Lin
AU  - Chan YL
FAU - Li, Tsung-Lin
AU  - Li TL
FAU - Wu, Chang-Jer
AU  - Wu CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110723
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (Antioxidants)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Plant Extracts)
RN  - 0 (Scutellaria baicalensis extract)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Animals
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Antioxidants/administration & dosage
MH  - Cachexia/*drug therapy
MH  - Carcinoma, Lewis Lung/*drug therapy/*immunology
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Fluorouracil/*administration & dosage
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Plant Extracts/*administration & dosage
MH  - Scutellaria baicalensis
MH  - Th1 Cells/drug effects
MH  - Th2 Cells/drug effects
EDAT- 2011/07/26 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/05/25 00:00 [revised]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S0959-8049(11)00476-X [pii]
AID - 10.1016/j.ejca.2011.06.048 [doi]
PST - ppublish
SO  - Eur J Cancer. 2012 May;48(7):1074-84. doi: 10.1016/j.ejca.2011.06.048. Epub 2011 
      Jul 23.