PMID- 21783476
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220408
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 19
IP  - 1
DP  - 2005 Jan
TI  - Effects of malathion subchronic exposure on rat skeletal muscle glucose 
      metabolism.
PG  - 191-6
LID - 10.1016/j.etap.2004.07.002 [doi]
AB  - Regarding the widespread use of organophosphorous pesticides (OP) especially 
      malathion in environment and reported cases of muscle disturbances in human and 
      animal, the present work was undertaken to explore effects of malathion 
      subchronic exposure on rat leg skeletal muscle glucose metabolism by measuring 
      key enzymes of glycogenolysis and glycolysis. Malathion was administered through 
      food for 4 weeks at concentrations of 100, 200, and 400ppm to rats. Activities of 
      enzymes including glycogen phosphorylase (GP), hexokinase (HK), and 
      phosphofructokinase-1 (PFK) were measured in skeletal muscle homogenate of 
      exposed rats. Levels of glucose and insulin were measured in blood. Four weeks 
      administration of malathion at doses of 200 and 400ppm increased blood glucose 
      concentrations to 44.4 and 60.6% of control, respectively. Malathion at doses of 
      200 and 400ppm increased blood insulin concentration to 36.6 and 143.2% of 
      control, respectively. Malathion at doses of 100, 200, and 400ppm increased 
      muscle PFK activity to 40.4, 53.5, and 83.1% of control, respectively. Malathion 
      at doses of 400ppm increased skeletal muscle GP to 91.6% of control. Skeletal 
      muscle HK was not influenced by malathion treatment. It is concluded that 
      malathion influences muscle glycogenolysis and glycolysis as well as secretion of 
      insulin from pancreas which all may explain diabetic potential of malathion.
FAU - Pournourmohammadi, Shirin
AU  - Pournourmohammadi S
AD  - Department of Toxicology and Pharmacology, Faculty of Pharmacy, and 
      Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, 
      Tehran, P.O. Box 14155-6451, Iran.
FAU - Farzami, Bijan
AU  - Farzami B
FAU - Ostad, Seyed Nasser
AU  - Ostad SN
FAU - Azizi, Ebrahim
AU  - Azizi E
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2005/01/01 00:00
MHDA- 2005/01/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2004/05/14 00:00 [received]
PHST- 2004/07/09 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2005/01/01 00:00 [pubmed]
PHST- 2005/01/01 00:01 [medline]
AID - S1382-6689(04)00110-3 [pii]
AID - 10.1016/j.etap.2004.07.002 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2005 Jan;19(1):191-6. doi: 10.1016/j.etap.2004.07.002.