PMID- 21783486
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 19
IP  - 2
DP  - 2005 Feb
TI  - Reduced thyroxine levels in mice perinatally exposed to polybrominated diphenyl 
      ethers.
PG  - 273-81
LID - 10.1016/j.etap.2004.08.001 [doi]
AB  - The aim of the study was to follow plasma thyroxine levels and hepatic enzyme 
      activities in offspring after maternal gestational and lactational exposure to 
      polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls. Mice were 
      given 10 equimolar oral doses from gestational day (GD) 4 to postnatal day (PND) 
      17 of either Bromkal 70-5DE, 2,2',4,4',5-pentabrominated diphenyl ether (BDE-99) 
      or Aroclor 1254 (total dose of 0.80mmol/kg, b.w.). Plasma thyroxine levels were 
      reduced in offspring in the Aroclor and Bromkal groups on PND11 but had returned 
      to control levels by PND37. No effects on thyroxine levels were seen in the dams. 
      Hepatic activity of EROD was increased in all treated offspring groups and so was 
      UDP-GT in Aroclor-exposed offspring on PND11 and PND18. This study shows that 
      PBDEs and PCBs, probably after microsomal transformation, have endocrine 
      disrupting properties in perinatally exposed juvenile mice, most pronounced at 
      PND11. However, BDE-99 had no effect on thyroxine levels, suggesting that other 
      components in Bromkal are responsible for the hypothyroxinemia.
FAU - Skarman, Ellen
AU  - Skarman E
AD  - Department of Biomedical Sciences and Veterinary Public Health, Swedish 
      University of Agricultural Sciences, PO Box 7078, SE-75007 Uppsala, Sweden.
FAU - Darnerud, Per Ola
AU  - Darnerud PO
FAU - Ohrvik, Helena
AU  - Ohrvik H
FAU - Oskarsson, Agneta
AU  - Oskarsson A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2005/02/01 00:00
MHDA- 2005/02/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2003/12/12 00:00 [received]
PHST- 2004/08/03 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2005/02/01 00:00 [pubmed]
PHST- 2005/02/01 00:01 [medline]
AID - S1382-6689(04)00143-7 [pii]
AID - 10.1016/j.etap.2004.08.001 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2005 Feb;19(2):273-81. doi: 
      10.1016/j.etap.2004.08.001.