PMID- 21783553
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 19
IP  - 3
DP  - 2005 May
TI  - Sex- and region-specific alterations of progesterone receptor mRNA levels and 
      estrogen sensitivity in rat brain following developmental exposure to the 
      estrogenic UV filter 4-methylbenzylidene camphor.
PG  - 761-5
LID - 10.1016/j.etap.2004.12.055 [doi]
AB  - Recently, we reported on in vitro and in vivo estrogenic activity of UV filters 
      and on developmental toxicity of 4-methylbenzylidene (4-MBC) camphor [Schlumpf, 
      M., Cotton, B., Conscience, M., Haller, V., Steinmann, B., Lichtensteiger, W., 
      2001a. In vitro and in vivo estrogenicity of UV screens. Environ. Health 
      Perspect. 109, 239; Schlumpf, M., Berger, L., Cotton, B., Conscience-Egli, M., 
      Durrer, S., Fleischmann, I., Haller, V., Maerkel, K., Lichtensteiger, W., 2001b. 
      Estrogen active UV screens. SOFW-J. 7, 10]. 4-MBC (7, 24, 47mg/(kgday)) was 
      administered in chow to long Evans rats from 10 weeks before mating of the parent 
      (F0) generation until adulthood of the F1 generation. Peripheral reproductive 
      organs and central nervous system were studied in adult offspring. mRNA 
      expression of progesterone receptor (PR), an estrogen-regulated gene, was 
      investigated in medial preoptic area (MPO) and ventromedial hypothalamic nucleus 
      (VMH) by real-time RT-PCR. We analyzed intact 12-week-old male and female 
      offspring under steady state conditions and adult gonadectomized offspring 6h 
      after a single s.c. injection of estradiol-17beta (E2) (10 or 50mug/kg) in order to 
      assess estrogen sensitivity. At steady state conditions we observed significantly 
      higher PR mRNA expression in VMH of control females versus control males. 4-MBC 
      exposed females exhibited a decrease in PR mRNA to levels of control males. The 
      increase in PR mRNA in response to E2 was higher in VMH of males of both 4-MBC 
      groups as compared to control males. PR mRNA levels were similar in MPO of 
      control males and females. Developmental 4-MBC exposure increased PR mRNA levels 
      in male MPO, but did not significantly change female levels. The acute response 
      to the lower E2 dose was decreased in MPO of 4-MBC-exposed males, whereas females 
      of the 7mg/kg dose group exhibited an increased reaction to 50mug/kg of E2. Our 
      data indicate that developmental exposure to endocrine active chemicals such as 
      the UV filter 4-MBC can interfere with sexually dimorphic gene expression in 
      brain in a sex- and region-specific manner.
FAU - Maerkel, Kirsten
AU  - Maerkel K
AD  - Institute of Pharmacology and Toxicology, University of Zurich, 
      Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
FAU - Lichtensteiger, Walter
AU  - Lichtensteiger W
FAU - Durrer, Stefan
AU  - Durrer S
FAU - Conscience, Marianne
AU  - Conscience M
FAU - Schlumpf, Margret
AU  - Schlumpf M
LA  - eng
PT  - Journal Article
DEP - 20050217
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2005/05/01 00:00
MHDA- 2005/05/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2005/05/01 00:00 [pubmed]
PHST- 2005/05/01 00:01 [medline]
AID - S1382-6689(04)00309-6 [pii]
AID - 10.1016/j.etap.2004.12.055 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2005 May;19(3):761-5. doi: 10.1016/j.etap.2004.12.055. 
      Epub 2005 Feb 17.