PMID- 21783607
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 20
IP  - 2
DP  - 2005 Sep
TI  - Developmental toxicity evaluation of nerve growth factor for injection in Wistar 
      rats.
PG  - 321-5
LID - 10.1016/j.etap.2005.03.003 [doi]
AB  - Nerve growth factor (NGF) for injection is now used as an agent to cure 
      peripheral nerve injury. To assess its potential embryo-lethal and teratogenic 
      toxicity, five groups of pregnant Wistar rats received 0, 40, 200 and 1000U/kg 
      NGF by muscle injection from gestational days (GD) 6 to 17. Maternal body weight 
      was monitored at regular intervals throughout gestation. We selected 7mg/kg body 
      weight cyclophosphamide (CPA) given to positive control group testing the Wistar 
      rats of this study whether sensitive to teratogens or not. The dams were 
      euthanized on GD 20, the day just before expected parturition. All fetuses were 
      removed by cesarean section and examined for external, visceral and skeletal 
      malformations under a dissecting microscope. There were no treatment-related 
      maternal deaths. Our statistical findings were a reduction in maternal body 
      weight and the occurrence of fetal body length shorten in 1000U/(kgday) dose 
      group, which suggesting mild embryotoxicity of NGF. There were no major changes 
      observed in other doses groups such as viable fetuses rate, resorption and dead 
      fetuses rate, external, skeletal, visceral abnormality, fetal weight and length, 
      tail length, indicating no evident maternal toxicity, embryotoxicity and 
      teratogenicity resulted from NGF. Thus, it seems a favorable preclinical safety 
      evaluation profile for NGF.
FAU - Liu, Wei
AU  - Liu W
AD  - Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, No. 1 Xian Nong Tan Street, Postal code 100050, Beijing, China.
FAU - Wang, Aiping
AU  - Wang A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2005/09/01 00:00
MHDA- 2005/09/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2004/09/08 00:00 [received]
PHST- 2005/03/11 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2005/09/01 00:00 [pubmed]
PHST- 2005/09/01 00:01 [medline]
AID - S1382-6689(05)00071-2 [pii]
AID - 10.1016/j.etap.2005.03.003 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2005 Sep;20(2):321-5. doi: 10.1016/j.etap.2005.03.003.