PMID- 21783639
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 21
IP  - 1
DP  - 2006 Jan
TI  - Pentachlorophenol inhibits micronuclei induction by 2-acetylaminofluorene but not 
      by thioacetamide.
PG  - 56-60
LID - 10.1016/j.etap.2005.07.013 [doi]
AB  - Our study examined the capacity of pentachlorophenol (PCP) to inhibit the ability 
      of 2-acetylaminofluorene (2-AAF) and thioacetamide (TAA) to induce micronuclei in 
      mouse bone marrow cells in vivo. 2-AAF (5.6mg/kg) and TAA (60mg/kg) were 
      administered intra-peritoneally (i.p.) to Mus musculus males (BALB/c), and the 
      frequencies of polychromatic erythrocytes with micronuclei (PCE-MN) 24h after 
      injection were analyzed. Treatment with 2-AAF or TAA resulted in high PCE-MN 
      frequencies in comparison with untreated and negative controls (19.9 and 21.6 per thousand, 
      respectively, versus  approximately 3 per thousand). Pretreatment with a single PCP dose (44mg/kg) 24h 
      prior to the 2-AAF administration virtually eliminated micronuclei formation by 
      2-AAF, although it had no inhibitory effect on TAA-induced micronuclei. Animals 
      receiving cyclophosphamide (CP) served as positive control. Since PCP is known to 
      inhibit arylsulfotransferase (AST) activity, which is involved in 2-AAF 
      activation, this mechanism most likely produced the results with PCP and 2-AAF. 
      Our results also are consistent with a different pathway involved in TAA 
      induction of micronuclei, one that is not inhibited by PCP.
FAU - Zamorano-Ponce, E
AU  - Zamorano-Ponce E
AD  - Laboratorio de Genetica Toxicologica (GENETOX), Departamento de Ciencias Basicas, 
      Facultad de Ciencias, Universidad del Bio-Bio, Casilla 447, Chillan, Chile.
FAU - Romero, J Fernandez
AU  - Romero JF
FAU - Rivera Caamano, P
AU  - Rivera Caamano P
FAU - Guerra, C Barrios
AU  - Guerra CB
LA  - eng
PT  - Journal Article
DEP - 20050912
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2006/01/01 00:00
MHDA- 2006/01/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2004/05/05 00:00 [received]
PHST- 2005/06/28 00:00 [revised]
PHST- 2005/07/01 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2006/01/01 00:00 [pubmed]
PHST- 2006/01/01 00:01 [medline]
AID - S1382-6689(05)00140-7 [pii]
AID - 10.1016/j.etap.2005.07.013 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2006 Jan;21(1):56-60. doi: 10.1016/j.etap.2005.07.013. 
      Epub 2005 Sep 12.