PMID- 21783685
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 22
IP  - 1
DP  - 2006 Jul
TI  - Effects of diazinon on pseudocholinesterase activity and haematological indices 
      in rats: The protective role of Vitamin E.
PG  - 46-51
LID - 10.1016/j.etap.2005.11.007 [doi]
AB  - Diazinon (DZN) is an organophosphate insecticide has been used in agriculture and 
      domestic for several years. Vitamin E (200mg/kg, twice a week), diazinon 
      (10mg/kg, per day) and Vitamin E (200mg/kg, twice a week)+diazinon (10mg/kg, per 
      day) combination were given to rats orally via gavage for 7 weeks. 
      Pseudocholinesterase in serum and haematological indices were investigated at the 
      end of the 1st, 4th and 7th weeks comparatively with control group. At the end of 
      1st, 4th and 7th weeks, statistically significant decrease of 
      pseudocholinesterase activity in serum were detected when diazinon- and Vitamin 
      E+diazinon-treated groups compared to control group. When diazinon- and Vitamin 
      E+diazinon-treated groups were compared to each other there were no significant 
      changes. When diazinon-treated group was compared to control group, body weight 
      decreased significantly at the end of the 4th and 7th weeks. It was observed that 
      at the end of 1st, 4th and 7th weeks, there was a statistically significance in 
      haematological indices except mean corpuscular hemoglobin (MCH) when 
      diazinon-treated group was compared to control group. At the end of 1st week 
      increase of thrombocyte, at the end of the 4th week increase of hemoglobin and 
      thrombocyte and at the end of the 7th week increase of red blood cell (RBC), 
      hemoglobin, hematocrit, mean corpuscular hemoglobin concentration (MCHC) and 
      thrombocyte were observed statistically significant when Vitamin E+diazinon 
      treated group was compared with diazinon treated group. According to the present 
      study, we conclude that Vitamin E reduces diazinon toxicity, but it does not 
      protect completely.
FAU - Kalender, Yusuf
AU  - Kalender Y
AD  - Gazi University, Faculty of Arts and Science, Biology Department, 06500 Ankara, 
      Turkey.
FAU - Uzunhisarcikli, Meltem
AU  - Uzunhisarcikli M
FAU - Ogutcu, Ayse
AU  - Ogutcu A
FAU - Acikgoz, Fatma
AU  - Acikgoz F
FAU - Kalender, Suna
AU  - Kalender S
LA  - eng
PT  - Journal Article
DEP - 20060118
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2006/07/01 00:00
MHDA- 2006/07/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2005/07/26 00:00 [received]
PHST- 2005/11/23 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2006/07/01 00:00 [pubmed]
PHST- 2006/07/01 00:01 [medline]
AID - S1382-6689(05)00204-8 [pii]
AID - 10.1016/j.etap.2005.11.007 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2006 Jul;22(1):46-51. doi: 10.1016/j.etap.2005.11.007. 
      Epub 2006 Jan 18.