PMID- 21783819
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1382-6689 (Print)
IS  - 1382-6689 (Linking)
VI  - 24
IP  - 3
DP  - 2007 Nov
TI  - Phosphorylation of Stats at Ser727 in renal proximal tubular epithelial cells 
      exposed to cadmium.
PG  - 252-9
LID - 10.1016/j.etap.2007.06.002 [doi]
AB  - The effects of cadmium exposure on serine phosphorylation of signal transducers 
      and activators of transcription (Stats) and an upstream kinase were examined in 
      renal proximal tubular cells. In porcine LLC-PK1 cells treated with cadmium, 
      Stat1 and Stat3 proteins were phosphorylated at Ser727 without changing total 
      Stat protein levels. While phosphorylated forms of the members of 
      mitogen-activated protein kinases (MAPKs) increased in response to cadmium 
      exposure, treatment with a p38 inhibitor, SB203580 reduced Ser727 phosphorylation 
      of Stat1 and Stat3 markedly in LLC-PK1 cells. The expression of human matrix 
      metalloproteinase-3 (MMP-3), a Stats-inducible gene, was found to be up-regulated 
      in human HK-2 cells exposed to cadmium, and suppressed by preincubation with 
      SB203580. These results suggest that cadmium might induce the phosphorylation of 
      Stat1 and Stat3 at Ser727 via the p38 pathway at least in part, and modulate gene 
      expression in these proximal tubular cells.
CI  - Copyright (c) 2007 Elsevier B.V. All rights reserved.
FAU - Nakagawa, Junko
AU  - Nakagawa J
AD  - Department of Hygiene and Public Health I, Tokyo Women's Medical University, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
FAU - Nishitai, Gen
AU  - Nishitai G
FAU - Inageda, Kiyoshi
AU  - Inageda K
FAU - Matsuoka, Masato
AU  - Matsuoka M
LA  - eng
PT  - Journal Article
DEP - 20070615
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2007/11/01 00:00
MHDA- 2007/11/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2007/03/31 00:00 [received]
PHST- 2007/06/02 00:00 [revised]
PHST- 2007/06/10 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2007/11/01 00:00 [pubmed]
PHST- 2007/11/01 00:01 [medline]
AID - S1382-6689(07)00083-X [pii]
AID - 10.1016/j.etap.2007.06.002 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2007 Nov;24(3):252-9. doi: 10.1016/j.etap.2007.06.002. 
      Epub 2007 Jun 15.