PMID- 21784029
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110725
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 28
IP  - 3
DP  - 2009 Nov
TI  - The inducibility of human cytochrome P450 1A by environmental-relevant 
      xenobiotics in the human hepatoma derived cell line HepG2.
PG  - 370-8
LID - 10.1016/j.etap.2009.06.005 [doi]
AB  - Overexpression of the CYP1 family, independent of gender, is focal to the 
      evaluation of the risk of human cancer. We have analysed the ability of 17 
      anthropogenic environmental xenobiotics widely used in Europe within households 
      and agriculture to induce the human cytochrome P450 1A (CYP1A) in the human 
      hepatoma derived cell line HepG2. The xenobiotics were potent to concomitantly 
      induce both CYP1A mRNA and CYP1A activity in a dose-response relationship. 
      Exceptions were shown by the organophosphate insecticide chlorpyrifos and the 
      imidazole fungicide prochloraz in high concentrations which were capable of both 
      inhibiting the basal or abolishing the initially induced CYP1A activity, 
      respectively. A CYP1A induction has been shown for the first time by the aromatic 
      xenobiotics irgasan, permethrin and azoxystrobin, the nonaromatic 
      tributyltinoxide and for humans by the piperonylbutoxide. The xenobiotics 
      additionally differed by their induced CYP1A isoenzyme pattern. A pronounced 
      CYP1A1 and CYP1A2 mRNA induction was given by the phenyl urea herbicide diuron 
      and benzodiazole insecticide piperonylbutoxide, respectively. In conclusion, out 
      of the environmental xenobiotics, we described new members of human CYP1A 
      inducers which extend chemical structures of biotransformation activators.
CI  - Copyright (c) 2009 Elsevier B.V. All rights reserved.
FAU - Rudzok, Susanne
AU  - Rudzok S
AD  - Helmholtz Centre for Environmental Research - UFZ, Department of Environmental 
      Immunology, Permoserstr. 15, 04318 Leipzig, Germany.
FAU - Schmucking, Eike
AU  - Schmucking E
FAU - Graebsch, Carolin
AU  - Graebsch C
FAU - Herbarth, Olf
AU  - Herbarth O
FAU - Bauer, Mario
AU  - Bauer M
LA  - eng
PT  - Journal Article
DEP - 20090623
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2009/11/01 00:00
MHDA- 2009/11/01 00:01
CRDT- 2011/07/26 06:00
PHST- 2009/03/16 00:00 [received]
PHST- 2009/06/02 00:00 [revised]
PHST- 2009/06/13 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2009/11/01 00:00 [pubmed]
PHST- 2009/11/01 00:01 [medline]
AID - S1382-6689(09)00114-8 [pii]
AID - 10.1016/j.etap.2009.06.005 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8. doi: 10.1016/j.etap.2009.06.005. 
      Epub 2009 Jun 23.