PMID- 21784614
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20161125
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan
TI  - Hypolipidimic and antioxidant activities of virgin olive oil and its fractions in 
      2,4-diclorophenoxyacetic acid-treated rats.
PG  - 81-91
LID - 10.1016/j.nut.2011.02.009 [doi]
AB  - OBJECTIVE: We examined the effects of extra virgin olive oil (EVOO) and its 
      hydrophilic and lipophilic fractions on serum lipids, oxidative stress, and 
      morphologic and functional liver damages induced by 2,4-diclorophenoxyacetic acid 
      (2,4-D). METHODS: Male Wistar rats were divided randomly into eight groups: 
      control; 2,4-D at a dose of 5 mg/kg of body weight (2,4-D); 2,4-D plus EVOO 
      (2,4-D/EVOO); 2,4-D plus the hydrophilic fraction (2,4-D/OOHF); 2,4-D plus the 
      lipophilic fraction (2,4-D/OOLF); only EVOO (EVOO); only the hydrophilic fraction 
      (OOHF); and only the lipophilic fraction (OOLF). These components were 
      administered daily by gavage for 4 wk. RESULTS: A hepatic architecture 
      aberration, increased activities of aspartate and alanine aminotransferase 
      enzymes, total and low-density lipoprotein cholesterol, and malondialdehyde (MDA) 
      level, and a decreased antioxidant defense system were observed in the 2,4-D 
      group. The administration of EVOO restored the damage caused by 2,4-D by a 
      significant decrease of plasma total and low-density lipoprotein levels and a 
      moderate increase of high-density lipoprotein cholesterol. The 2,4-D/OOHF group 
      exhibited a pronounced enhancement of the antioxidant defense system by an 
      increase of superoxide dismutase, catalase, and glutathione peroxidase levels and 
      a decrease of plasma and liver MDA levels. However, less improvement in the liver 
      histoarchitecture and antioxidant status was observed in rats supplemented with 
      OOLF diet, despite its richness in alpha-tocopherol. CONCLUSION: Extra virgin olive 
      oil may be a potential functional food source of antioxidants than can decrease 
      the frequency of cardiovascular diseases and liver damage.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Nakbi, Amel
AU  - Nakbi A
AD  - Biochemistry Laboratory, UR03/ES08, Human Nutrition and Metabolic Disorders, USCR 
      Mass Spectrometry, Faculty of Medicine of Monastir, Monastir, Tunisia. 
      nakbia@yahoo.fr
FAU - Tayeb, Wafa
AU  - Tayeb W
FAU - Dabbou, Samia
AU  - Dabbou S
FAU - Chargui, Issam
AU  - Chargui I
FAU - Issaoui, Manel
AU  - Issaoui M
FAU - Zakhama, Abdelfattah
AU  - Zakhama A
FAU - Miled, Abdelhedi
AU  - Miled A
FAU - Hammami, Mohamed
AU  - Hammami M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110723
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Antioxidants)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Olive Oil)
RN  - 0 (Pesticides)
RN  - 0 (Plant Oils)
RN  - 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid)
RN  - EC 1.- (Oxidoreductases)
SB  - IM
MH  - 2,4-Dichlorophenoxyacetic Acid/*toxicity
MH  - Animals
MH  - Antioxidants/chemistry/*therapeutic use
MH  - Atherosclerosis/etiology/prevention & control
MH  - Chemical Fractionation
MH  - Chemical and Drug Induced Liver 
      Injury/blood/pathology/physiopathology/*prevention & control
MH  - Food Handling
MH  - Hepatic Insufficiency/etiology/prevention & control
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Hyperlipoproteinemias/etiology/prevention & control
MH  - Hypolipidemic Agents/chemistry/*therapeutic use
MH  - Lipid Peroxidation/drug effects
MH  - Liver/drug effects/metabolism/*pathology/physiopathology
MH  - Male
MH  - Olive Oil
MH  - Oxidative Stress
MH  - Oxidoreductases/blood/metabolism
MH  - Pesticides/*toxicity
MH  - Plant Oils/chemistry/*therapeutic use
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Risk Factors
EDAT- 2011/07/26 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/07/26 06:00
PHST- 2010/09/22 00:00 [received]
PHST- 2010/12/15 00:00 [revised]
PHST- 2011/02/15 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - S0899-9007(11)00088-8 [pii]
AID - 10.1016/j.nut.2011.02.009 [doi]
PST - ppublish
SO  - Nutrition. 2012 Jan;28(1):81-91. doi: 10.1016/j.nut.2011.02.009. Epub 2011 Jul 
      23.