PMID- 21785041
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20120301
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 27
IP  - 3
DP  - 2012 Mar
TI  - Gender differences in the association between HDL cholesterol and the progression 
      of diabetic kidney disease in type 2 diabetic patients.
PG  - 1070-5
LID - 10.1093/ndt/gfr417 [doi]
AB  - BACKGROUND: The impact of serum lipid abnormalities on the progression of 
      diabetic kidney disease (DKD) remains conflicting. Furthermore, gender 
      differences in the association between dyslipidaemia and outcome of DKD are 
      largely unknown. We therefore conducted this single-centre observational cohort 
      study to clarify gender differences in the association between serum lipid 
      profiles and the progression of DKD. METHODS: Seven hundred and twenty-three 
      Japanese type 2 diabetes mellitus (T2DM) patients with normoalbuminuria or 
      microalbuminuria, 280 women and 443 men, with a mean (+/- SD) age of 63 +/- 11 years 
      were studied. The endpoint was the progression to a more advanced stage of 
      albuminuria. For statistical analyses, Cox proportional hazard model analyses 
      were conducted. RESULTS: During the mean follow-up period of 4.3 years, 62 of 477 
      patients with normoalbuminuria and 69 of 246 patients with microalbuminuria 
      reached the endpoint. A significant interaction between high-density lipoprotein 
      (HDL) cholesterol and gender was detected (P(interaction) = 0.04); therefore, 
      separate analyses were conducted for men and women. Overall, in men, the 
      univariate Cox proportional hazard model revealed that higher triglycerides and 
      lower HDL cholesterol levels were significantly associated with higher risk of 
      reaching the endpoint. In the multivariate Cox proportional hazard model, only 
      HDL cholesterol levels remained as an independent predictor of the endpoint 
      (hazard ratio 0.391, P = 0.01). In women, no serum lipid parameters were 
      associated with the endpoint. CONCLUSIONS: Lower HDL cholesterol levels seem to 
      be associated with the progression of DKD in men but not in women.
FAU - Hanai, Ko
AU  - Hanai K
AD  - Division of Nephrology and Hypertension, Diabetes Centre, Tokyo Women's Medical 
      University School of Medicine, Tokyo, Japan.
FAU - Babazono, Tetsuya
AU  - Babazono T
FAU - Yoshida, Naoshi
AU  - Yoshida N
FAU - Nyumura, Izumi
AU  - Nyumura I
FAU - Toya, Kiwako
AU  - Toya K
FAU - Hayashi, Toshihide
AU  - Hayashi T
FAU - Bouchi, Ryotaro
AU  - Bouchi R
FAU - Tanaka, Nobue
AU  - Tanaka N
FAU - Ishii, Akiko
AU  - Ishii A
FAU - Iwamoto, Yasuhiko
AU  - Iwamoto Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110722
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/etiology/metabolism/pathology
MH  - Cholesterol, HDL/*metabolism
MH  - Cohort Studies
MH  - Diabetes Complications/*etiology/metabolism/pathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Nephropathies/*etiology/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
MH  - Sex Factors
MH  - Triglycerides/metabolism
MH  - Young Adult
EDAT- 2011/07/26 06:00
MHDA- 2012/09/15 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - gfr417 [pii]
AID - 10.1093/ndt/gfr417 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2012 Mar;27(3):1070-5. doi: 10.1093/ndt/gfr417. Epub 
      2011 Jul 22.