PMID- 21785113
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20221214
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Print)
IS  - 1672-9145 (Linking)
VI  - 43
IP  - 9
DP  - 2011 Sep
TI  - Spatial regulation of the mTORC1 system in amino acids sensing pathway.
PG  - 671-9
LID - 10.1093/abbs/gmr066 [doi]
AB  - The mammalian target of rapamycin (mTOR) is an evolutionarily conserved 
      serine/threonine protein kinase that regulates numerous cellular processes 
      including cell growth, proliferation, cell cycle, and autophagy. mTOR forms two 
      different multi-protein complexes referred to as mTOR complex 1 (mTORC1) and 
      mTORC2, and each complex exerts distinct functions exclusively. mTORC1 activity 
      is sensitive to the selective inhibitor rapamycin, whereas mTORC2 is resistant. 
      mTORC1 is regulated by many intra- and extra-cellular cues such as growth 
      factors, nutrients, and energy-sensing signals, while mTORC2 senses ribosome 
      maturation and growth factor signaling. This review focuses on current 
      understandings by which mTORC1 pathway senses cellular nutrient availability for 
      its activation.
FAU - Suzuki, Tsukasa
AU  - Suzuki T
AD  - Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
FAU - Inoki, Ken
AU  - Inoki K
LA  - eng
GR  - R01 DK124709/DK/NIDDK NIH HHS/United States
GR  - DK083491/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110723
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Amino Acids)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Neuropeptides)
RN  - 0 (Proteins)
RN  - 0 (RHEB protein, human)
RN  - 0 (Ras Homolog Enriched in Brain Protein)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.6.5.2 (Monomeric GTP-Binding Proteins)
SB  - IM
MH  - Amino Acids/*metabolism/pharmacology
MH  - Animals
MH  - Enzyme Activation/drug effects
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Models, Biological
MH  - Monomeric GTP-Binding Proteins/metabolism
MH  - Multiprotein Complexes
MH  - Neuropeptides/metabolism
MH  - Proteins/*metabolism
MH  - Ras Homolog Enriched in Brain Protein
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3160786
EDAT- 2011/07/26 06:00
MHDA- 2012/01/31 06:00
PMCR- 2012/09/01
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - gmr066 [pii]
AID - 10.1093/abbs/gmr066 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):671-9. doi: 
      10.1093/abbs/gmr066. Epub 2011 Jul 23.