PMID- 21785226
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 75
IP  - 10
DP  - 2011
TI  - Dynamics of reactive oxygen metabolites and biological antioxidant potential in 
      the acute stage of Kawasaki disease.
PG  - 2453-9
AB  - BACKGROUND: The dynamics of oxidation/reduction control system activities using 
      reactive oxygen metabolites (ROM) and biological antioxidant potential (BAP) in 
      acute stage patients was evaulated to understand the mechanism of vascular injury 
      and remodeling in Kawasaki disease (KD). METHODS AND RESULTS: ROM, BAP, 
      high-sensitivity C-reactive protein (hs-CRP), interleukin-1,2,6, and tumour 
      necrosis factor-alpha in 19 KD patients were measured. ROM decreased in good 
      correlation only with hs-CRP (P<0.05) at 2 weeks after intravenous immunoglobulin 
      (IVIG). Patients were further classified as responding well (Group A) or 
      responding poorly (Group B) to IVIG. Both treatment groups had significantly 
      higher ROM values than the control group (P<0.01). ROM decreased in Group A both 
      immediately and 2 weeks after the IVIG treatment (P<0.05), but it did not 
      decrease in Group B until 2 weeks post-treatment (P<0.01). BAP levels were 
      unremarkable in Group A, but were significantly lower in Group B than in both 
      other groups (P<0.05). BAP increased in Group A 2 weeks after IVIG treatment 
      (P<0.01), but remained low in Group B (P<0.01). CONCLUSIONS: Acute stage KD 
      patients suffer from obvious hyperoxidant stress, and improved in response to 
      IVIG treatment in most patients. Blood BAP level might be a useful index for 
      predicting responsiveness to IVIG the treatment.
FAU - Yahata, Tomoyo
AU  - Yahata T
AD  - Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University 
      of Medicine Graduate School of Medical Science, Kyoto, Japan.
FAU - Suzuki, Chinatsu
AU  - Suzuki C
FAU - Hamaoka, Akiko
AU  - Hamaoka A
FAU - Fujii, Maiko
AU  - Fujii M
FAU - Hamaoka, Kenji
AU  - Hamaoka K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110723
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Antioxidants)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Acute Disease
MH  - Antioxidants/*metabolism
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/therapeutic use
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/complications/*drug therapy/*metabolism
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reactive Oxygen Species/*metabolism
MH  - Treatment Outcome
MH  - Vasculitis/etiology
EDAT- 2011/07/26 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-10-0605 [pii]
AID - 10.1253/circj.cj-10-0605 [doi]
PST - ppublish
SO  - Circ J. 2011;75(10):2453-9. doi: 10.1253/circj.cj-10-0605. Epub 2011 Jul 23.