PMID- 21785662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1874-3900 (Print)
IS  - 1874-3900 (Linking)
VI  - 4
IP  - 2
DP  - 2011 Jun
TI  - Thyrsiferol Inhibits Mitochondrial Respiration and HIF-1 Activation.
PG  - 75-78
AB  - The cytotoxic marine red algal metabolite thyrsiferol (1) was found to inhibit 
      hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D human 
      breast tumor cells (66% inhibition at 3 muM). Compound 1 also suppressed hypoxic 
      induction of HIF-1 target genes (VEGF, GLUT-1) at the mRNA level, and displayed 
      tumor cell line-selective time-dependent inhibition of cell 
      viability/proliferation. Mechanistic studies revealed that 1 selectively 
      suppressed mitochondrial respiration at Complex I (IC(50) 3 muM). Thyrsiferol 
      represents a prototypical, structurally unique electron transport chain 
      inhibitor. The apparent rotenone-like activity may contribute to the observed 
      cytotoxicity of 1 and play an important role in Laurencia chemical defense.
FAU - Mahdi, Fakhri
AU  - Mahdi F
AD  - Department of Pharmacognosy, School of Pharmacy, University of Mississippi, 
      University, MS 38677, United States.
FAU - Falkenberg, Miriam
AU  - Falkenberg M
FAU - Ioannou, Efstathia
AU  - Ioannou E
FAU - Roussis, Vassilios
AU  - Roussis V
FAU - Zhou, Yu-Dong
AU  - Zhou YD
FAU - Nagle, Dale G
AU  - Nagle DG
LA  - eng
GR  - R01 CA098787-05A2/CA/NCI NIH HHS/United States
GR  - R01 CA098787-06/CA/NCI NIH HHS/United States
GR  - C06 RR014503/RR/NCRR NIH HHS/United States
GR  - R01 CA098787/CA/NCI NIH HHS/United States
GR  - R56 CA098787-05A1/CA/NCI NIH HHS/United States
GR  - R56 CA098787/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Phytochem Lett
JT  - Phytochemistry letters
JID - 101513432
PMC - PMC3139250
MID - NIHMS238862
EDAT- 2011/07/26 06:00
MHDA- 2011/07/26 06:01
PMCR- 2012/06/01
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2011/07/26 06:01 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - 10.1016/j.phytol.2010.09.003 [doi]
PST - ppublish
SO  - Phytochem Lett. 2011 Jun;4(2):75-78. doi: 10.1016/j.phytol.2010.09.003.