PMID- 21786089
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Print)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 11
DP  - 2011 Nov
TI  - Cardiac involvement in Wegener's granulomatosis resistant to induction therapy.
PG  - 2297-304
LID - 10.1007/s00330-011-2203-6 [doi]
AB  - OBJECTIVES: The aim of the study was to assess cardiac involvement in patients 
      with Wegener's granulomatosis (WG), who failed to achieve remission following >6 
      months induction therapy for life or organ threatening disease. METHODS: Eleven 
      WG patients (eight males, mean age 47 +/- 13 years), who failed to achieve 
      remission despite >6 months induction therapy, underwent transthoracic 
      echocardiography (TTE) and cardiac magnetic resonance (CMR). RESULTS: Cardiac 
      involvement was present in 9 (82%) patients. Regional wall motion abnormalities 
      were found in two individuals, but none had left ventricular (LV) ejection 
      fraction <50%. Nine patients had late gadolinium enhancement (LGE) lesions 
      involving LV myocardium and right ventricle free wall was involved in four 
      patients. LGE lesions were found in subepicardial, midwall and subendocardial LV 
      myocardial layers. CMR revealed myocarditis in six patients. Patients with 
      myocarditis had a higher number of LV segments with LGE (5.2 +/- 3.4 vs 1.0 +/- 1.2, 
      p = 0.03) and more frequent diastolic dysfunction by TTE (5 vs 0, p = 0.02) than 
      those without. Pericardial effusion was observed in five patients, while 
      localized pericardial thickening in six patients. CONCLUSIONS: In WG resistant to 
      >6 months induction therapy cardiac involvement is frequent and is characterized 
      by foci of LGE lesions and signs of myocardial inflammatory process.
FAU - Miszalski-Jamka, Tomasz
AU  - Miszalski-Jamka T
AD  - Center for Diagnosis, Prevention and Telemedicine, John Paul II Hospital, ul. 
      Pradnicka 80, 31-202 Krakow, Poland. miszalt@mp.pl
FAU - Szczeklik, Wojciech
AU  - Szczeklik W
FAU - Sokolowska, Barbara
AU  - Sokolowska B
FAU - Miszalski-Jamka, Karol
AU  - Miszalski-Jamka K
FAU - Karwat, Krzysztof
AU  - Karwat K
FAU - Grzadziel, Gabriel
AU  - Grzadziel G
FAU - Mazur, Wojciech
AU  - Mazur W
FAU - Kereiakes, Dean J
AU  - Kereiakes DJ
FAU - Musial, Jacek
AU  - Musial J
LA  - eng
PT  - Journal Article
DEP - 20110723
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adult
MH  - Diagnostic Imaging/methods
MH  - Echocardiography/*methods
MH  - Female
MH  - Granulomatosis with Polyangiitis/*diagnosis
MH  - Heart/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnosis/pathology
MH  - Remission Induction
PMC - PMC3184393
EDAT- 2011/07/26 06:00
MHDA- 2012/01/24 06:00
PMCR- 2011/07/23
CRDT- 2011/07/26 06:00
PHST- 2011/02/13 00:00 [received]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/05/12 00:00 [revised]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
PHST- 2011/07/23 00:00 [pmc-release]
AID - 2203 [pii]
AID - 10.1007/s00330-011-2203-6 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Nov;21(11):2297-304. doi: 10.1007/s00330-011-2203-6. Epub 2011 
      Jul 23.