PMID- 21786159
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 4
DP  - 2012 Apr
TI  - Association of two porcine reproductive and respiratory syndrome virus (PRRSV) 
      receptor genes, CD163 and SN with immune traits.
PG  - 3971-6
LID - 10.1007/s11033-011-1177-4 [doi]
AB  - CD163 and sialoadhesin (SN) were reported as two essential receptors for the 
      porcine reproductive and respiratory syndrome virus. To investigate the 
      relationship between these two genes and porcine immunity, we assigned porcine 
      CD163 and SN respectively to SSC5q21-q24 and SSC17q23 by IMpRH. Expression 
      profiles revealed that CD163 and SN were ubiquitously expressed in ten tissues, 
      and were expressed highly in lymph gland, spleen and liver, which implied the 
      potential functions of CD163 and SN in immunity. Moreover, a single nucleotide 
      polymorphism (SNP) c.3534C>T was found in 3'-UTR of the CD163 gene and 
      association analysis showed that this gene was significantly associated with the 
      IgG content in blood (P < 0.05). A novel missense mutation c.878A>G located in 
      exon4 of the SN gene which caused the amino acid transition from histidine to 
      arginine was detected, and it was significantly associated with the WBC count in 
      the peripheral blood (P < 0.05). These results provided fundamental evidence for 
      CD163 and SN as two functional candidate genes affecting immunity in pigs.
FAU - Wang, Fengli
AU  - Wang F
AD  - Laboratory of Molecular Biology and Animal Breeding, Key Laboratory of 
      Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, 
      Huazhong Agricultural University, Wuhan, 430070, China.
FAU - Qiu, Haifang
AU  - Qiu H
FAU - Zhang, Qingde
AU  - Zhang Q
FAU - Peng, Zhongzhen
AU  - Peng Z
FAU - Liu, Bang
AU  - Liu B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110724
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Virus)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 1)
SB  - IM
MH  - Animals
MH  - Antigens, CD/*genetics
MH  - Antigens, Differentiation, Myelomonocytic/*genetics
MH  - Chromosomes, Mammalian/genetics
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - *Genetic Association Studies
MH  - Genotype
MH  - Membrane Glycoproteins/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Porcine respiratory and reproductive syndrome virus/*metabolism
MH  - Quantitative Trait, Heritable
MH  - Receptors, Cell Surface/*genetics
MH  - Receptors, Immunologic/*genetics
MH  - Receptors, Virus/*genetics
MH  - Sialic Acid Binding Ig-like Lectin 1
MH  - Sus scrofa/genetics/*immunology/*virology
EDAT- 2011/07/26 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/01/20 00:00 [received]
PHST- 2011/07/02 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - 10.1007/s11033-011-1177-4 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Apr;39(4):3971-6. doi: 10.1007/s11033-011-1177-4. Epub 2011 
      Jul 24.