PMID- 21787579
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110726
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jan
TI  - High-dose dibutyl phthalate improves performance of F1 generation male rats in 
      spatial learning and increases hippocampal BDNF expression independent on p-CREB 
      immunocontent.
PG  - 32-8
LID - 10.1016/j.etap.2009.09.003 [doi]
AB  - Dibutyl phthalate (DBP), an important representative of endocrine disrupting 
      chemical, is suspected of affecting the cognitive function of humans and animals. 
      In this study, effects of DBP on maze performance in male rats were evaluated by 
      spatial learning tasks; the effects of DBP on the expression of brain-derived 
      neurotrophic factor (BDNF) were also analyzed in both mRNA and mature protein 
      levels in the hippocampus, with intent to investigate the possible mechanism 
      underlying the behavioral findings. Pregnant Wistar rats were treated orally by 
      gavage with 0, 25, 75, 225 and 675mgDBP/kgBW/day from gestational day (GD) 6 to 
      postnatal day (PND) 21, and then the weaned offspring continued receiving the 
      same treatment till PND 28. We found that male pups treated with high-dose DBP 
      showed enhancement in spatial acquisition in a Morris water maze during PNDs 
      30-33, and displayed better retention of spatial memory in a probe trial after a 
      reverse trail during PNDs 60-62. Real-time PCR and western blotting analysis of 
      the hippocampus from DBP-treated male rats on PND 21 revealed an increase in BDNF 
      expression, compared to the vehicle-matched control. BDNF variant III, a 
      transcription promoted by active CREB (i.e. p-CREB), as well as the immunocontent 
      of p-CREB, was scarcely altered by the treatment. Our results suggest that 
      developmental treatment with high-dose DBP improves spatial memory in male rats, 
      and this effect may be related to an increase in BDNF expression in the 
      hippocampus in a p-CREB independent route.
CI  - Copyright (c) 2009 Elsevier B.V. All rights reserved.
FAU - Li, Yuanfeng
AU  - Li Y
AD  - Department of Health Toxicology, MOE Key Laboratory of Environmental and Health, 
      Tongji Medical College of Huazhong University of Science and Technology, No. 13, 
      Hangkong Road, Wuhan 430030, Hubei, China.
FAU - Li, Tao
AU  - Li T
FAU - Zhuang, Meizhu
AU  - Zhuang M
FAU - Wang, Kailiang
AU  - Wang K
FAU - Zhang, Juan
AU  - Zhang J
FAU - Shi, Nian
AU  - Shi N
LA  - eng
PT  - Journal Article
DEP - 20090908
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/07/27 06:00
PHST- 2009/02/23 00:00 [received]
PHST- 2009/07/15 00:00 [revised]
PHST- 2009/09/02 00:00 [accepted]
PHST- 2011/07/27 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - S1382-6689(09)00149-5 [pii]
AID - 10.1016/j.etap.2009.09.003 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2010 Jan;29(1):32-8. doi: 10.1016/j.etap.2009.09.003. 
      Epub 2009 Sep 8.