PMID- 21788302
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20141120
IS  - 1569-9285 (Electronic)
IS  - 1569-9285 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Oct
TI  - Preoperative carriage and postoperative same-species sternal wound infection 
      after cardiac surgery.
PG  - 381-5
LID - 10.1510/icvts.2011.275362 [doi]
AB  - Sternal wound infection (SWI) after cardiac surgery remains an important problem. 
      Prediction of pathogens involved in such infection could guide antibiotics. From 
      April 1, 2006 to December 31, 2008, retrospectively, we evaluated the diagnostic 
      value of preoperative methicillin-sensible Staphylococcus aureus (MSSA), 
      methicillin-resistant S. aureus (MRSA) or multi-drug resistant Gram-negative 
      bacillus (MDRGNB) carriage to predict same-pathogens involved in postoperative 
      SWI. All patients referred for elective cardiac surgery were screened using 
      multisite (nares, axillae, rectal) sampling at admission to detect MSSA, MRSA, 
      and MDRGNB. Of the 1895 patients addressed, 425 patients (22.4%) were colonized 
      at admission. Preoperative carriers more frequently developed SWI than 
      non-carriers, respectively, 11% vs. 5.5% (P<0.05). Because of the small sample, 
      MDRGNB carriers could not be analyzed. For prediction of MSSA SWI with 
      preoperative MSSA carriage, the area under the receiver operating characteristic 
      (ROC) curve was 0.720 (95% confidence interval (CI), 0.364-0.796) and 0.710 (95% 
      CI, 0.623-0.787) for prediction of MRSA SWI with preoperative MRSA carriage. 
      Preoperative MSSA carriage is frequent but preoperative MRSA or MDRGNB carriage 
      remains infrequent. The ability of preoperative carriage to predict a 
      same-pathogen-postoperative SWI was low and should not be used to guide empirical 
      antibiotherapy.
FAU - Maillet, Jean-Michel
AU  - Maillet JM
AD  - Department of Cardio Vascular and Thoracic Intensive Care, Centre Cardiologique 
      du Nord, Saint-Denis, France. jm.maillet@ccncardio.com
FAU - Oghina, Gregoire
AU  - Oghina G
FAU - Le Besnerais, Paul
AU  - Le Besnerais P
FAU - Thierry, Stephane
AU  - Thierry S
FAU - Bouquet, Genevieve
AU  - Bouquet G
FAU - Mesnildrey, Patrick
AU  - Mesnildrey P
FAU - Bonnet, Nicolas
AU  - Bonnet N
FAU - Brodaty, Denis
AU  - Brodaty D
LA  - eng
PT  - Journal Article
DEP - 20110725
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Bacterial Infections/drug therapy/*microbiology/transmission
MH  - Cardiac Surgical Procedures/*adverse effects
MH  - *Drug Resistance, Multiple, Bacterial
MH  - Elective Surgical Procedures
MH  - Female
MH  - France
MH  - Gram-Negative Bacteria/*isolation & purification
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Methicillin-Resistant Staphylococcus aureus/isolation & purification
MH  - Microbial Sensitivity Tests
MH  - Middle Aged
MH  - Nasal Cavity/microbiology
MH  - Odds Ratio
MH  - Perineum/microbiology
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Skin/microbiology
MH  - Staphylococcus aureus/*isolation & purification
MH  - Sternotomy/*adverse effects
MH  - Surgical Wound Infection/drug therapy/*microbiology/transmission
EDAT- 2011/07/27 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - icvts.2011.275362 [pii]
AID - 10.1510/icvts.2011.275362 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2011 Oct;13(4):381-5. doi: 
      10.1510/icvts.2011.275362. Epub 2011 Jul 25.