PMID- 21788502
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 108
IP  - 33
DP  - 2011 Aug 16
TI  - Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase 
      suppresses tumorigenesis in mice lacking Rb1 or Men1.
PG  - 13379-86
LID - 10.1073/pnas.1110104108 [doi]
AB  - Aberrations in epigenetic processes, such as histone methylation, can cause 
      cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can 
      demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic 
      marks for transcriptionally active chromatin, whereas the multiple endocrine 
      neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous 
      studies suggested that inhibition of RBP2 contributed to tumor suppression by the 
      retinoblastoma protein (pRB). Here, we show that genetic ablation of Rbp2 
      decreases tumor formation and prolongs survival in Rb1(+/-) mice and 
      Men1-defective mice. These studies link RBP2 histone demethylase activity to 
      tumorigenesis and nominate RBP2 as a potential target for cancer therapy.
FAU - Lin, Wenchu
AU  - Lin W
AD  - Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and 
      Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
FAU - Cao, Jian
AU  - Cao J
FAU - Liu, Jiayun
AU  - Liu J
FAU - Beshiri, Michael L
AU  - Beshiri ML
FAU - Fujiwara, Yuko
AU  - Fujiwara Y
FAU - Francis, Joshua
AU  - Francis J
FAU - Cherniack, Andrew D
AU  - Cherniack AD
FAU - Geisen, Christoph
AU  - Geisen C
FAU - Blair, Lauren P
AU  - Blair LP
FAU - Zou, Mike R
AU  - Zou MR
FAU - Shen, Xiaohua
AU  - Shen X
FAU - Kawamori, Dan
AU  - Kawamori D
FAU - Liu, Zongzhi
AU  - Liu Z
FAU - Grisanzio, Chiara
AU  - Grisanzio C
FAU - Watanabe, Hideo
AU  - Watanabe H
FAU - Minamishima, Yoji Andrew
AU  - Minamishima YA
FAU - Zhang, Qing
AU  - Zhang Q
FAU - Kulkarni, Rohit N
AU  - Kulkarni RN
FAU - Signoretti, Sabina
AU  - Signoretti S
FAU - Rodig, Scott J
AU  - Rodig SJ
FAU - Bronson, Roderick T
AU  - Bronson RT
FAU - Orkin, Stuart H
AU  - Orkin SH
FAU - Tuck, David P
AU  - Tuck DP
FAU - Benevolenskaya, Elizaveta V
AU  - Benevolenskaya EV
FAU - Meyerson, Matthew
AU  - Meyerson M
FAU - Kaelin, William G Jr
AU  - Kaelin WG Jr
FAU - Yan, Qin
AU  - Yan Q
LA  - eng
SI  - GEO/GSE26446
SI  - GEO/GSE26978
GR  - CA16359/CA/NCI NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - CA138631/CA/NCI NIH HHS/United States
GR  - R01 CA138631/CA/NCI NIH HHS/United States
GR  - R01 CA076120/CA/NCI NIH HHS/United States
GR  - P30 CA016359/CA/NCI NIH HHS/United States
GR  - CA076120/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110725
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Histones)
RN  - 0 (Men1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Rbp2 protein, mouse)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Retinol-Binding Proteins, Cellular)
RN  - EC 1.14.11.- (Histone Demethylases)
SB  - IM
MH  - Animals
MH  - Enzyme Inhibitors/therapeutic use
MH  - Epigenomics
MH  - Histone Demethylases
MH  - Histones/metabolism
MH  - Methylation
MH  - Mice
MH  - Mice, Knockout
MH  - Neoplasms/enzymology/etiology/*prevention & control
MH  - Proto-Oncogene Proteins/*deficiency
MH  - Retinoblastoma Protein/*deficiency
MH  - Retinol-Binding Proteins, Cellular/antagonists & inhibitors/*deficiency
MH  - Survival Rate
PMC - PMC3158206
COIS- The authors declare no conflict of interest.
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
PMCR- 2012/02/16
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2012/02/16 00:00 [pmc-release]
AID - 1110104108 [pii]
AID - 201110104 [pii]
AID - 10.1073/pnas.1110104108 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13379-86. doi: 
      10.1073/pnas.1110104108. Epub 2011 Jul 25.