PMID- 21788909
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20221207
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Print)
IS  - 1070-8022 (Linking)
VI  - 32
IP  - 1
DP  - 2012 Mar
TI  - Optic nerve head drusen in black patients.
PG  - 13-6
LID - 10.1097/WNO.0b013e3182268655 [doi]
AB  - BACKGROUND: Several studies have suggested racial differences in the prevalence 
      of optic nerve head drusen (ONHD). We aimed to determine the percentage of 
      patients with ONHD who are black and to describe the clinical, ophthalmoscopic, 
      and perimetric findings in these patients. METHODS: We conducted a retrospective 
      chart review of all patients with ONHD seen at our institution between 1989 and 
      2010. Only black patients with ONHD confirmed on either funduscopy or B-scan 
      ultrasonography were included. Demographic and clinical findings in these 
      patients were recorded and analyzed. RESULTS: Of the 196 patients with confirmed 
      ONHD, 10 (5.1%) were black. This included 7 females and 3 males with ages ranging 
      from 8 to 61 years. Six of the 10 patients had bilateral ONHD. The ONHD were 
      buried in 11 of 16 eyes and exposed in 5 of 16 eyes. Fifteen of 16 eyes with ONHD 
      had small cupless optic nerve heads. Visual fields were normal in 4 of 16 eyes 
      with ONHD. In the remainder, visual field defects included an enlarged blind spot 
      (5 eyes), constricted field (5 eyes), nasal defect (2 eyes), central defect (1 
      eye), and generalized depression (1 eye). Visual field defects were present in 4 
      of 5 eyes (80%) with exposed ONHD and 8 of 11 eyes (72.7%) with buried ONHD. None 
      of the patients were related, and none of their examined family members had 
      exposed ONHD on funduscopic examination. CONCLUSIONS: ONHD are rare in blacks, 
      possibly due to the presence of a larger cup-to-disc ratio or a lack of 
      predisposing genetic factors. Visual field defects are common in black patients 
      with both exposed and buried ONHD.
FAU - Thurtell, Matthew J
AU  - Thurtell MJ
AD  - Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, 
      USA.
FAU - Biousse, Valerie
AU  - Biousse V
FAU - Bruce, Beau B
AU  - Bruce BB
FAU - Newman, Nancy J
AU  - Newman NJ
LA  - eng
GR  - KL2 TR000455/TR/NCATS NIH HHS/United States
GR  - P30 EY006360/EY/NEI NIH HHS/United States
GR  - KL2 RR025009/RR/NCRR NIH HHS/United States
GR  - K23-EY019341/EY/NEI NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - P30-EY06360/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black or African American/genetics
MH  - Black People/*genetics
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Disk Drusen/*ethnology/etiology/*physiopathology
MH  - Papilledema/ethnology/etiology/*physiopathology
MH  - Retrospective Studies
MH  - Vision Disorders/ethnology/etiology/*physiopathology
MH  - Young Adult
PMC - PMC3459063
MID - NIHMS403646
COIS- Disclosure: The authors report no conflicts of interest
EDAT- 2011/07/27 06:00
MHDA- 2012/11/06 06:00
PMCR- 2013/03/01
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 10.1097/WNO.0b013e3182268655 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2012 Mar;32(1):13-6. doi: 10.1097/WNO.0b013e3182268655.