PMID- 2178962
OWN - NLM
STAT- MEDLINE
DCOM- 19900426
LR  - 20151119
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 3
IP  - 2
DP  - 1990 Feb
TI  - Bronchial responsiveness in patients with mitral valve disease.
PG  - 127-31
AB  - Bronchial responsiveness has been evaluated in patients with chronic lung 
      congestion secondary to mitral valve disease. Methacholine bronchial challenge 
      was performed by intermittent aerosol generation in 31 patients with mitral valve 
      disease, 18 in New York Heart Association (NYHA) Class II and 13 in NYHA Class 
      III, non-atopic and with baseline forced expiratory volume in one second/vital 
      capacity (FEV1/VC) greater than 85% of predicted and in 30 normal controls. 
      Haemodynamic data were available in 17 patients. The methacholine bronchial 
      provocation dose causing a 35% fall of airway conductance (PD35sGaw) was 
      significantly lower in patients (507 +/- C.I. 205 micrograms) than in normals 
      (2779 +/- C.I. 358 micrograms), (p less than 0.001). In patients log PD35sGaw was 
      significantly correlated with mean pulmonary artery pressure (r = 0.53, p less 
      than 0.05), mean pulmonary capillary wedge pressure (r = 0.67, p less than 0.01), 
      but not with any spirometric parameters. Bronchial hyperresponsiveness seems to 
      be common in patients with mitral valve disease and evidence of lung congestion.
FAU - Rolla, G
AU  - Rolla G
AD  - Clinica Medica I, University of Torino, Italy.
FAU - Bucca, C
AU  - Bucca C
FAU - Caria, E
AU  - Caria E
FAU - Scappaticci, E
AU  - Scappaticci E
FAU - Baldi, S
AU  - Baldi S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Methacholine Compounds)
RN  - 0W5ETF9M2K (Methacholine Chloride)
SB  - IM
MH  - Bronchial Provocation Tests
MH  - Bronchial Spasm/*diagnosis/physiopathology
MH  - Dyspnea, Paroxysmal/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Methacholine Chloride
MH  - Methacholine Compounds
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*physiopathology
MH  - Mitral Valve Stenosis/*physiopathology
MH  - Spirometry
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1990 Feb;3(2):127-31.