PMID- 21790601
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120227
LR  - 20111101
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 56
IP  - 6
DP  - 2011 Nov
TI  - Development of microwave-assisted extraction procedure for organic impurity 
      profiling of seized 3,4-methylenedioxymethamphetamine (MDMA).
PG  - 1483-92
LID - 10.1111/j.1556-4029.2011.01848.x [doi]
AB  - Organic impurity profiling of seized 3,4-methylenedioxymethamphetamine (MDMA) 
      tablets aims to link tablets to common production sources. Conventionally, 
      organic impurities are extracted from tablets using a liquid-liquid extraction 
      (LLE) procedure prior to analysis by gas chromatography-mass spectrometry 
      (GC-MS). In this research, the development of an alternative microwave-assisted 
      extraction/headspace solid-phase microextraction (MAE/HS-SPME) procedure is 
      described. The optimal procedure used phosphate buffer (1 M, pH 8), with an 
      HS-SPME extraction temperature of 70  degrees C for 40 min, using a 
      divinylbenzene/Carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber. Impurities 
      were extracted from seized MDMA exhibits using the MAE/HS-SPME procedure, as well 
      as HS-SPME alone, and a conventional LLE procedure. The HS-SPME procedure was 
      deemed to be the most practical because of the affordability and need for less 
      analyst involvement. Although the LLE was limited in the number of impurities 
      extracted, the procedure is still useful for the extraction of less volatile 
      impurities that are not extracted by HS-SPME.
CI  - (c) 2011 American Academy of Forensic Sciences.
FAU - Giebink, Patricia J
AU  - Giebink PJ
AD  - Forensic Science Program, School of Criminal Justice, Michigan State University, 
      East Lansing, MI 48824, USA.
FAU - Smith, Ruth Waddell
AU  - Smith RW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110725
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
EDAT- 2011/07/28 06:00
MHDA- 2011/07/28 06:01
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/07/28 06:01 [medline]
AID - 10.1111/j.1556-4029.2011.01848.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2011 Nov;56(6):1483-92. doi: 10.1111/j.1556-4029.2011.01848.x. 
      Epub 2011 Jul 25.