PMID- 21791526
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20211203
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 138
IP  - 16
DP  - 2011 Aug
TI  - An emerging role for TOR signaling in mammalian tissue and stem cell physiology.
PG  - 3343-56
LID - 10.1242/dev.058230 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of 
      signals, ranging from nutrient availability and energy status, to cellular 
      stressors, oxygen sensors and growth factors. The finely tuned response of mTOR 
      to these stimuli results in alterations to cell metabolism and cell growth. 
      Recent studies of conditional knockouts of mTOR pathway components in mice have 
      affirmed the role of mTOR signaling in energy balance, both at the cell and whole 
      organism levels. Such studies have also highlighted a role for mTOR in stem cell 
      homeostasis and lifespan determination. Here, we discuss the molecular mechanisms 
      of TOR signaling and review recent in vitro and in vivo studies of mTOR 
      tissue-specific activities in mammals.
FAU - Russell, Ryan C
AU  - Russell RC
AD  - Department of Pharmacology and Moores Cancer Center, University of California at 
      San Diego, La Jolla, CA 92093-0815, USA. kuguan@ucsd.edu
FAU - Fang, Chong
AU  - Fang C
FAU - Guan, Kun-Liang
AU  - Guan KL
LA  - eng
GR  - CA108941/CA/NCI NIH HHS/United States
GR  - GM51586/GM/NIGMS NIH HHS/United States
GR  - R01 GM062694/GM/NIGMS NIH HHS/United States
GR  - R01 GM051586/GM/NIGMS NIH HHS/United States
GR  - R01 CA108941/CA/NCI NIH HHS/United States
GR  - GM62694/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Homeostasis
MH  - Humans
MH  - *Signal Transduction/drug effects
MH  - Stem Cells/cytology/*metabolism
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/*metabolism
PMC - PMC3143559
EDAT- 2011/07/28 06:00
MHDA- 2011/10/15 06:00
PMCR- 2012/08/15
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
PHST- 2012/08/15 00:00 [pmc-release]
AID - 138/16/3343 [pii]
AID - 10.1242/dev.058230 [doi]
PST - ppublish
SO  - Development. 2011 Aug;138(16):3343-56. doi: 10.1242/dev.058230.