PMID- 21791870
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20221207
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 75
IP  - 10
DP  - 2011
TI  - Depression and outcomes in hospitalized Japanese patients with cardiovascular 
      disease. - Prospective single-center observational study-.
PG  - 2465-73
AB  - BACKGROUND: Several studies have suggested that depression poses a risk in 
      cardiovascular patients. The aim of the present study was to evaluate the 
      prevalence of depression and its effect on cardiovascular events and mortality in 
      Japanese inpatients with cardiovascular disease. METHODS AND RESULTS: A total of 
      505 patients hospitalized with cardiovascular disease (28% female; mean age, 61 +/- 
      14 years; 31% ischemic heart disease; 47% New York Heart Association [NYHA] class 
      II-IV; 25% implantation of pacing devices) were enrolled in the present 
      prospective observational study. The Zung Self-Rating Depression Scale (SDS) was 
      used to screen for depression. The primary outcome was the time to death or 
      cardiovascular event, and the secondary outcome was death. In total, 109 patients 
      (22%) were diagnosed with depression (Zung SDS index score >/= 60). NYHA class 
      III/IV, defibrillator implantation, and being unmarried were independently 
      associated with depression. During an average follow-up period of 38 +/- 15 months, 
      92 patients (18%) reached the primary outcome. There was a higher incidence of 
      the primary outcome in patients with depression than in those who were not 
      depressed (P<0.01). Depressed patients had a significantly higher rate of 
      mortality than non-depressed patients (P<0.01). Depression was an independent 
      predictor of the primary outcome (hazard ratio, 2.25; 95% confidence interval: 
      1.30-3.92, P<0.01). CONCLUSIONS: Depression was not uncommon in Japanese 
      inpatients with cardiovascular disease and was associated with cardiovascular 
      outcomes.
FAU - Suzuki, Tsuyoshi
AU  - Suzuki T
AD  - Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Shiga, Tsuyoshi
AU  - Shiga T
FAU - Kuwahara, Kazue
AU  - Kuwahara K
FAU - Kobayashi, Sayaka
AU  - Kobayashi S
FAU - Suzuki, Shinichi
AU  - Suzuki S
FAU - Nishimura, Katsuji
AU  - Nishimura K
FAU - Suzuki, Atsushi
AU  - Suzuki A
FAU - Omori, Hisako
AU  - Omori H
FAU - Mori, Fumiaki
AU  - Mori F
FAU - Ishigooka, Jun
AU  - Ishigooka J
FAU - Kasanuki, Hiroshi
AU  - Kasanuki H
FAU - Hagiwara, Nobuhisa
AU  - Hagiwara N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110727
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Aged
MH  - Asian People
MH  - *Cardiovascular Diseases/complications/mortality
MH  - Depression/complications/mortality
MH  - *Depressive Disorder/complications/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observation
MH  - Prevalence
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2011/07/28 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-11-0140 [pii]
AID - 10.1253/circj.cj-11-0140 [doi]
PST - ppublish
SO  - Circ J. 2011;75(10):2465-73. doi: 10.1253/circj.cj-11-0140. Epub 2011 Jul 27.