PMID- 21791969
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20211020
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 35
IP  - 6
DP  - 2012 Jun
TI  - Peripheral bone mineral density in correlation to disease-related predisposing 
      conditions in patients with multiple endocrine neoplasia type 1.
PG  - 573-9
LID - 10.3275/7880 [doi]
AB  - BACKGROUND AND AIM: Patients with multiple endocrine neoplasia type 1 (MEN1) 
      often have low bone mineral density (BMD) attributed to primary 
      hyperparathyroidism (pHPT). However, in MEN1 patients, other endocrine 
      dysfunctions and conditions such as hypercortisolism, hypogonadism, and GH 
      deficiency due to pituitary manifestation, and surgery on the upper 
      gastrointestinal tract may affect BMD. SUBJECTS AND METHODS: In 23 patients with 
      MEN1 (10 females, 13 males; 46+/-12 yr), BMD was determined by quantitative 
      computed tomography at the forearm (pqCT), compared to a reference population and 
      related to different conditions suspected to affect bone metabolism in MEN1. 
      RESULTS: In this cohort, Z-score for trabecular BMD was -0.85+/-1.18 and for total 
      BMD -1.16+/-1.04. There was a similar trend towards lower BMD in uncontrolled 
      hyperparathyroidism, hypercortisolism, hypogonadism/GH deficiency and the state 
      after surgery at the upper gastrointestinal tract. CONCLUSIONS: These data while 
      confirming previous observations on reduced BMD in patients with MEN1, however, 
      challenge its only or even predominant association with pHPT. Other conditions 
      such as hypercortisolism, somatotrophic/ gonadotrophic pituitary insufficiency, 
      and previous upper gastrointestinal surgery seem to be factors contributing to 
      the risk of developing osteoporosis.
FAU - Kann, P H
AU  - Kann PH
AD  - Division of Endocrinology and Diabetology, Faculty of Medicine and University 
      Hospital, Philipp's University, Marburg, Germany. kannp@med.uni-marburg.de
FAU - Bartsch, D
AU  - Bartsch D
FAU - Langer, P
AU  - Langer P
FAU - Waldmann, J
AU  - Waldmann J
FAU - Hadji, P
AU  - Hadji P
FAU - Pfutzner, A
AU  - Pfutzner A
FAU - Klusener, J
AU  - Klusener J
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Bone Density
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism, Primary/*etiology/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications/pathology/surgery
MH  - Prognosis
MH  - Young Adult
EDAT- 2011/07/28 06:00
MHDA- 2012/12/12 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 7880 [pii]
AID - 10.3275/7880 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2012 Jun;35(6):573-9. doi: 10.3275/7880. Epub 2011 Jul 27.