PMID- 21792089
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20220318
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Print)
IS  - 0275-004X (Linking)
VI  - 31
IP  - 8
DP  - 2011 Sep
TI  - Macular features from spectral-domain optical coherence tomography as an adjunct 
      to indirect ophthalmoscopy in retinopathy of prematurity.
PG  - 1470-82
LID - 10.1097/IAE.0b013e31821dfa6d [doi]
AB  - PURPOSE: To compare vitreoretinal pathology imaged with portable handheld 
      spectral-domain optical coherence tomography (SD-OCT) to conventional indirect 
      ophthalmoscopic examination in neonates undergoing screening for retinopathy of 
      prematurity. METHODS: Spectral-domain optical coherence tomography images were 
      collected from 76 eyes of 38 neonates during 118 routine retinopathy of 
      prematurity examinations. Imaging sessions in the Neonatal Intensive Care Unit 
      were performed immediately after the subjects underwent a standard ophthalmic 
      examination with indirect ophthalmoscopic by a pediatric ophthalmologist. Masked 
      certified SD-OCT graders evaluated scans for preretinal and retinal findings 
      including material in the vitreous, epiretinal membrane, intraretinal cystoid 
      structures and deposits, optic nerve and vascular features, and severity and 
      location of retinopathy of prematurity. The frequency of detection of these 
      features by clinical examination and evaluation of SD-OCT images was compared to 
      determine potential clinical advantages for each modality. RESULTS: Portable 
      SD-OCT imaging characterized macular features of retinal cystoid structures in 
      39% of examinations and epiretinal membrane in 32% of examinations. Neither 
      feature was visualized by indirect ophthalmoscopy in any cases. The clinician 
      using indirect ophthalmoscopy detected stage of retinopathy of prematurity and 
      the presence or absence of Plus or pre-Plus disease. These were not visualized 
      with SD-OCT. CONCLUSION: Spectral-domain optical coherence tomography provides 
      new information about the premature infant retina that is of unknown importance 
      relative to visual development and acuity. As used in this study, SD-OCT does not 
      replace indirect ophthalmoscopy for evaluation of retinopathy of prematurity.
FAU - Lee, Annie C
AU  - Lee AC
AD  - Department of Ophthalmology, Duke University Medical Center, Duke University, 
      Durham, North Carolina 27710, USA.
FAU - Maldonado, Ramiro S
AU  - Maldonado RS
FAU - Sarin, Neeru
AU  - Sarin N
FAU - O'Connell, Rachelle V
AU  - O'Connell RV
FAU - Wallace, David K
AU  - Wallace DK
FAU - Freedman, Sharon F
AU  - Freedman SF
FAU - Cotten, Michael
AU  - Cotten M
FAU - Toth, Cynthia A
AU  - Toth CA
LA  - eng
GR  - UL1 RR024128/RR/NCRR NIH HHS/United States
GR  - UL1 RR024128-01/RR/NCRR NIH HHS/United States
GR  - 1UL1 RR024128-01/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
SB  - IM
MH  - Birth Weight
MH  - Epiretinal Membrane/diagnosis
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Macular Edema/diagnosis
MH  - Male
MH  - Ophthalmoscopy/*methods
MH  - Retina/*pathology
MH  - Retinopathy of Prematurity/*diagnosis
MH  - Tomography, Optical Coherence/*methods
MH  - Vitreous Body/*pathology
PMC - PMC3165115
MID - NIHMS294583
EDAT- 2011/07/28 06:00
MHDA- 2012/01/14 06:00
PMCR- 2012/09/01
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 10.1097/IAE.0b013e31821dfa6d [doi]
PST - ppublish
SO  - Retina. 2011 Sep;31(8):1470-82. doi: 10.1097/IAE.0b013e31821dfa6d.