PMID- 21792376
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20240506
IS  - 1874-1924 (Electronic)
IS  - 1874-1924 (Linking)
VI  - 5
DP  - 2011
TI  - Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in 
      Insulin Resistance, Diabetes and Heart Failure.
PG  - 153-63
LID - 10.2174/1874192401105010153 [doi]
AB  - Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) 
      generation. NO is a reactive oxygen species as well as a reactive nitrogen 
      species. It is a free radical which mediates several biological effects. It is 
      clear that the generation and actions of NO under physiological and 
      pathophysiological conditions are regulated and extend to almost every cell type 
      and function within the circulation. In mammals 3 distinct isoforms of NOS have 
      been identified: neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS 
      (eNOS). The important isoform in the regulation of insulin resistance (IR) is 
      iNOS. Understanding the molecular mechanisms regulating the iNOS pathway in 
      normal and hyperglycemic conditions would help to explain some of vascular 
      abnormalities observed in type 2 diabetes mellitus (T2DM). Previous studies have 
      reported increased myocardial iNOS activity and expression in heart failure (HF). 
      This review considers the recent animal studies which focus on the understanding 
      of regulation of iNOS activity/expression and the role of iNOS agonists as 
      potential therapeutic agents in treatment of IR, T2DM and HF.
FAU - Soskic, Sanja S
AU  - Soskic SS
AD  - Laboratory for Radiobiology and Molecular Genetics, Institute "Vinca", University 
      of Belgrade, Serbia.
FAU - Dobutovic, Branislava D
AU  - Dobutovic BD
FAU - Sudar, Emina M
AU  - Sudar EM
FAU - Obradovic, Milan M
AU  - Obradovic MM
FAU - Nikolic, Dragana M
AU  - Nikolic DM
FAU - Djordjevic, Jelena D
AU  - Djordjevic JD
FAU - Radak, Djordje J
AU  - Radak DJ
FAU - Mikhailidis, Dimitri P
AU  - Mikhailidis DP
FAU - Isenovic, Esma R
AU  - Isenovic ER
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - United Arab Emirates
TA  - Open Cardiovasc Med J
JT  - The open cardiovascular medicine journal
JID - 101480504
PMC - PMC3141344
OTO - NOTNLM
OT  - Inducible nitric oxide synthase
OT  - diabetes
OT  - heart failure.
OT  - insulin resistance
EDAT- 2011/07/28 06:00
MHDA- 2011/07/28 06:01
PMCR- 2011/01/01
CRDT- 2011/07/28 06:00
PHST- 2011/05/25 00:00 [received]
PHST- 2011/05/30 00:00 [revised]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/07/28 06:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - TOCMJ-5-153 [pii]
AID - 10.2174/1874192401105010153 [doi]
PST - ppublish
SO  - Open Cardiovasc Med J. 2011;5:153-63. doi: 10.2174/1874192401105010153. Epub 2011 
      Jul 7.