PMID- 21794006
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110728
IS  - 1740-0929 (Electronic)
IS  - 1344-3941 (Linking)
VI  - 82
IP  - 4
DP  - 2011 Aug
TI  - Tumor necrosis factor-alpha-induced inflammatory responses in cattle.
PG  - 504-11
LID - 10.1111/j.1740-0929.2011.00931.x [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is recognized as a cytokine because of its 
      involvement in inflammation-mediated biological defense functions. Although TNF-alpha 
      is primarily produced by macrophages, it is also produced by other cells, 
      including lymphocytes, Kupffer cells, natural killer cells and adipocytes. While 
      TNF-alpha has diverse immune system functions, including antitumor activity, 
      antimicrobial activity and mediation of inflammation, it also regulates a number 
      of physiological functions, including appetite, fever, energy metabolism and 
      endocrine activity. Factors such as viruses, parasites, other cytokines, and 
      endotoxins induce TNF-alpha production. In combination with other cytokines, TNF-alpha 
      plays a clinically important role in cattle by mediating immune inflammatory 
      responses such as mastitis and endotoxic shock. It has been reported that 
      cytokines such as TNF-alpha are involved in metabolic disease such as acidosis. On 
      the other hand, several data suggest that lactoferrin (LF) acts to prevent the 
      release of a number of inflammatory mediators from various activated cells, and 
      further suggest that the prophylactic effect of LF involves inhibition of 
      cytokine production, including TNF-alpha, that are principal mediators of the 
      inflammatory response leading to death from toxic shock. This review discusses 
      the role of TNF-alpha in pathological conditions in cattle, including infections and 
      metabolic diseases caused by perturbation of metabolism and endocrine functions.
CI  - 2011 The Author. Animal Science Journal (c) 2011 Japanese Society of Animal 
      Science.
FAU - Kushibiki, Shiro
AU  - Kushibiki S
AD  - National Institute of Livestock and Grassland Science, Tsukuba, Japan. 
      mendoza@affrc.go.jp
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110726
PL  - Australia
TA  - Anim Sci J
JT  - Animal science journal = Nihon chikusan Gakkaiho
JID - 100956805
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Cattle/physiology
MH  - Cattle Diseases/*physiopathology
MH  - Endocrine Glands/physiology
MH  - Female
MH  - Inflammation/physiopathology
MH  - Lactation/drug effects
MH  - Metabolic Diseases/physiopathology/veterinary
MH  - Tumor Necrosis Factor-alpha/pharmacology/*physiology
EDAT- 2011/07/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1740-0929.2011.00931.x [doi]
PST - ppublish
SO  - Anim Sci J. 2011 Aug;82(4):504-11. doi: 10.1111/j.1740-0929.2011.00931.x. Epub 
      2011 Jul 26.