PMID- 21794825
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20131121
IS  - 1885-1398 (Electronic)
IS  - 1699-258X (Linking)
VI  - 7
IP  - 4
DP  - 2011 Jul-Aug
TI  - [Economic evaluation of tramadol/paracetamol in the management of pain in 
      patients with osteoarthritis in Spain].
PG  - 241-7
LID - 10.1016/j.reuma.2010.11.016 [doi]
AB  - OBJECTIVE: To compare the costs of treating osteoarthritis (OA) pain using 
      combination tramadol/paracetamol tablets, Non-Steroidal Anti-Inflammatory Agents 
      (NSAID) alone or NSAID plus proton pump inhibitors (PPI) from the perspective of 
      the Spanish National Health System. METHODS: A decision-analytical model was 
      constructed to analyze the cost associated with three treatment strategies over 6 
      months. A cost-minimization approach was used, which considered data related to 
      resource use, medication costs and costs for the treatment of adverse events. 
      RESULTS: In the base-case analysis, costs for 6 months of treatment of OA pain 
      using tramadol/paracetamol were euro232.86, compared with euro274.60 for NSAID + PPI 
      and euro133.75 for NSAID alone. This provided a savings of euro41.74 per patient over 6 
      months for tramadol/paracetamol compared with NSAID + PPI and a cost increase of 
      euro99.11 compared with NSAID alone. When renal adverse events associated with NSAID 
      were considered, tramadol/paracetamol was cost saving compared with all 
      NSAID-based regimens (saving euro140.02 vs NSAID alone, euro280.86 vs NSAID + PPI). 
      CONCLUSION: Based on the results of a theoretical decision-analytic model, the 
      data obtained may suggest that tramadol/paracetamol is cost saving compared with 
      NSAID + PPI for the treatment of OA pain over a period of 6 months. 
      Tramadol/paracetamol is also cost saving compared with treatment with NSAID alone 
      if considering renal adverse events.
CI  - 2010 Elsevier Espana, S.L. All rights reserved.
FAU - Vidal, Javier
AU  - Vidal J
AD  - Servicio de Reumatologia, Hospital General Universitario de Guadalajara. 
      Guadalajara. Espana.
FAU - Benito, Pere
AU  - Benito P
FAU - Manresa, Anna
AU  - Manresa A
FAU - Ly-Pen, Domingo
AU  - Ly-Pen D
FAU - Batlle, Enrique
AU  - Batlle E
FAU - Blanco, Francisco J
AU  - Blanco FJ
FAU - Brosa, Max
AU  - Brosa M
FAU - Nieves, Diana
AU  - Nieves D
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Evaluacion economica de tramadol/paracetamol en el manejo del dolor en pacientes 
      con osteoartrosis en Espana.
DEP - 20110323
PL  - Spain
TA  - Reumatol Clin
JT  - Reumatologia clinica
JID - 101293923
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Analgesics, Opioid)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 39J1LGJ30J (Tramadol)
SB  - IM
MH  - Acetaminophen/*economics/*therapeutic use
MH  - Analgesics, Non-Narcotic/*therapeutic use
MH  - Analgesics, Opioid/*economics/*therapeutic use
MH  - Drug Therapy, Combination
MH  - Humans
MH  - Osteoarthritis/*complications
MH  - Pain/*drug therapy/*economics/etiology
MH  - Spain
MH  - Tramadol/*economics/*therapeutic use
EDAT- 2011/07/29 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/07/29 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2010/11/26 00:00 [revised]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - S1699-258X(11)00033-7 [pii]
AID - 10.1016/j.reuma.2010.11.016 [doi]
PST - ppublish
SO  - Reumatol Clin. 2011 Jul-Aug;7(4):241-7. doi: 10.1016/j.reuma.2010.11.016. Epub 
      2011 Mar 23.