PMID- 21796807
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20211020
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 12
IP  - 8
DP  - 2011 Aug
TI  - Association between SNP rs1800875, serum chymase and immunoglobulin E levels in 
      patients with coronary heart disease.
PG  - 660-7
LID - 10.1631/jzus.B1101008 [doi]
AB  - OBJECTIVE: The gene for mast cell chymase (CMA1) is an ideal candidate for 
      investigating the genetic predisposition to coronary heart disease (CHD), as 
      activated mast cells have been found to be present in a greater proportion in the 
      shoulder region of atheroma than in normal coronary intimae. Previous studies 
      have indicated that CMA1 promoter polymorphism rs1800875 may be involved in 
      regulating immunoglobulin E (IgE) levels in patients with eczema, and it is 
      associated with the progression of immunoglobulin A nephropathy. METHODS: The 
      association between single nucleotide polymorphism (SNP) rs1800875, serum 
      chymase, and serum IgE levels was examined in 175 CHD subjects and 95 non-CHD 
      subjects. RESULTS: Statistical analysis indicated no significant difference in 
      allele frequency between CHD and non-CHD. However, a significant association was 
      found between CMA1 genotypes and total IgE levels in CHD subjects. Meanwhile, 
      crossover analysis revealed that, in GG homozygotes, CHD risk was nearly six 
      times higher in those with IgE (U/ml) level <2.58 (natural logarithm conversion), 
      while no association was found with chymase level. CONCLUSIONS: Polymorphism 
      rs1800875 of CMA1 may be associated with serum IgE level in CHD subjects, but not 
      with chymase level in both groups. In GG homozygotes, high IgE level is a 
      protective factor against coronary disease.
FAU - Jin, Chun-Na
AU  - Jin CN
AD  - Department of Cardiology, the Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310009, China.
FAU - Ma, Hong
AU  - Ma H
FAU - Lin, Yan
AU  - Lin Y
FAU - Wang, Jian-An
AU  - Wang JA
FAU - Xiang, Mei-Xiang
AU  - Xiang MX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.21.39 (Chymases)
SB  - IM
MH  - Aged
MH  - Chymases/*blood/genetics
MH  - Constriction, Pathologic
MH  - Coronary Disease
MH  - Eczema/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/*blood/genetics
MH  - Male
MH  - Mast Cells/enzymology
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
PMC - PMC3150720
EDAT- 2011/07/29 06:00
MHDA- 2011/12/14 06:00
PMCR- 2011/08/01
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - 10.1631/jzus.B1101008 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2011 Aug;12(8):660-7. doi: 10.1631/jzus.B1101008.