PMID- 21798311
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20160614
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 502
IP  - 1
DP  - 2011 Sep 8
TI  - Decreased serum brain-derived neurotrophic factor levels in schizophrenic 
      patients with tardive dyskinesia.
PG  - 37-40
LID - 10.1016/j.neulet.2011.07.020 [doi]
AB  - The pathogenesis of tardive dyskinesia (TD) may involve neurodegeneration and 
      associated dysfunction of brain-derived neurotrophic factor (BDNF) for the 
      survival and maintenance of function in neurons. We therefore compared serum BDNF 
      levels in schizophrenic patients with (n=129) and without TD (n=235), and normal 
      controls (n=323). Assessments included the abnormal involuntary movement scale 
      (AIMS) and the positive and negative syndrome scale (PANSS). Our results were 
      that patients with TD had lower serum BDNF levels than those without TD and 
      normals. Lower serum BDNF levels were correlated with greater PANSS negative 
      subscores, but not correlated with the AIMS scores. Serum BDNF levels did not 
      differ between patients on typical and atypical antipsychotics and were not 
      correlated with antipsychotic doses or years of exposure. We concluded that 
      decreased BDNF levels might be associated with TD pathophysiology and more 
      negative symptoms of schizophrenia.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Yang, Yan Qiu
AU  - Yang YQ
AD  - The First Hospital of Jilin University, Changchun, China.
FAU - Sun, Shilong
AU  - Sun S
FAU - Yu, Ya Qin
AU  - Yu YQ
FAU - Li, Wen Jun
AU  - Li WJ
FAU - Zhang, Xuan
AU  - Zhang X
FAU - Xiu, Mei Hong
AU  - Xiu MH
FAU - Chen, Da Chun
AU  - Chen DC
FAU - De Yang, Fu
AU  - De Yang F
FAU - Liu, Haibo
AU  - Liu H
FAU - Li, Cunbo
AU  - Li C
FAU - Kosten, Thomas R
AU  - Kosten TR
FAU - Zhang, Xiang Yang
AU  - Zhang XY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110720
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Antipsychotic Agents/*adverse effects
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Dyskinesia, Drug-Induced/blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Movement Disorders/*blood/complications
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Schizophrenia/*blood/complications
MH  - Severity of Illness Index
EDAT- 2011/07/30 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/04/19 00:00 [received]
PHST- 2011/06/21 00:00 [revised]
PHST- 2011/07/07 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - S0304-3940(11)01068-8 [pii]
AID - 10.1016/j.neulet.2011.07.020 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Sep 8;502(1):37-40. doi: 10.1016/j.neulet.2011.07.020. Epub 
      2011 Jul 20.