PMID- 21799302
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20190727
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 224
IP  - 4
DP  - 2011 Aug
TI  - Association between plasma monocyte chemoattractant protein-1 levels and the 
      extent of atherosclerotic peripheral artery disease.
PG  - 301-6
AB  - Peripheral artery disease occurs at advanced ages and accounts for substantial 
      cardiovascular morbidity and mortality. Monocyte chemoattractant protein-1 
      (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the 
      cytokines involved in the pathogenesis of atherosclerosis and is also known as 
      cysteine-cysteine chemokine ligand 2 (CCL2). The aim of the current study was to 
      investigate the association between the extent of atherosclerotic peripheral 
      artery disease (PAD) and the increase in MCP-1 level. Eighty consecutive patients 
      who had undergone peripheral angiography for suspected PAD were included. Of 
      these patients, 48 (60%) had hypertension, 23 (28.8%) had type 2 diabetes 
      mellitus, 39 (48.8%) had a family history of coronary artery disease, 23 (28.8%) 
      were cigarette smokers, and 42 (52.5%) had hypercholesterolemia. Angiography 
      revealed that the peripheral arteries of the lower extremity were normal in 41 
      (51.3%) patients, whereas 39 (48.7%) patients had varying degrees of PAD. The 
      patients were queried regarding age, gender, and atherosclerotic risk factors. 
      The plasma MCP-1 levels were significantly lower in the patients without PAD than 
      those in the patients with PAD (172.27 +/- 38.05 pg/mL vs. 200.87 +/- 39.31 pg/mL, p 
      = 0.001). Moreover, as the severity of PAD increases, MCP-1 levels also increase. 
      Thus, the plasma MCP-1 level can be used in the diagnosis of PAD and in 
      determining the extent of atherosclerotic PAD of the lower extremities, as in 
      determining the extent of coronary artery disease.
CI  - (c) 2011 Tohoku University Medical Press
FAU - Satiroglu, Omer
AU  - Satiroglu O
AD  - Department of Cardiology, Rize University Faculty of Medicine, Rize, Turkey. 
      omersatiroglu@yahoo.com
FAU - Uydu, Huseyin Avni
AU  - Uydu HA
FAU - Demir, Adem
AU  - Demir A
FAU - Bostan, Mehmet
AU  - Bostan M
FAU - Atak, Mehtap
AU  - Atak M
FAU - Bozkurt, Engin
AU  - Bozkurt E
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Atherosclerosis/*blood/*pathology
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/*blood/*pathology
MH  - Risk Factors
EDAT- 2011/07/30 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - JST.JSTAGE/tjem/224.301 [pii]
AID - 10.1620/tjem.224.301 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2011 Aug;224(4):301-6. doi: 10.1620/tjem.224.301.