PMID- 21801323
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20191210
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 5
IP  - 4
DP  - 2011 Oct
TI  - Validation of the Finnish ISAAC questionnaire on asthma against anti-asthmatic 
      medication reimbursement database in 5-year-old children.
PG  - 211-8
LID - 10.1111/j.1752-699X.2010.00222.x [doi]
AB  - BACKGROUND: Valid identification of childhood asthma at the population level for 
      epidemiological purposes remains a challenge. We aimed at validating the Finnish 
      version of the International Study of Asthma and Allergies in Childhood (ISAAC) 
      questionnaire based on parental-reported childhood asthma. MATERIALS AND METHODS: 
      The ISAAC questionnaire has been validated against anti-asthmatic medication 
      reimbursement data of the Finnish Social Insurance Institution, being the gold 
      standard, among 2236 5-year-old consecutively born children (1996-2004) carrying 
      human leukocyte antigen (HLA)-conferred susceptibility to type 1 diabetes. Two 
      combined questionnaire questions (any wheezing symptom or use of asthma 
      medication during the preceding 12 months plus ever asthma; any wheezing symptom 
      or use of asthma medication during the preceding 12 months plus ever 
      doctor-diagnosed asthma) were validated against valid reimbursement with purchase 
      of at least one anti-asthmatic medication during a 12-month period. The validity 
      of the questionnaire was estimated as the sensitivity, specificity, positive 
      predictive value, negative predictive value, and Youden's index. RESULTS: The 
      sensitivity 0.98 [95% confidence interval (CI) = 0.92-0.99]; specificity 0.98 
      (95% CI = 0.97-0.98); negative predictive value 1.00 (95% CI = 1.00-1.00); and 
      Youden's index 0.96 (95% CI = 0.96-0.96) were the same for each of the two sets 
      of combined questions. The positive predictive value for the first combined 
      question was 0.63 (95% CI = 0.55-0.71), while it was 0.64 (95% CI = 0.57-0.72) 
      for the second combined question. CONCLUSION: The Finnish ISAAC questionnaire was 
      highly valid and is an acceptable instrument for the survey of the prevalence of 
      parental-reported childhood asthma for epidemiological purposes.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Nwaru, Bright Ibeabughichi
AU  - Nwaru BI
AD  - Tampere School of Public Health, University of Tampere, Finland. 
      bright.nwaru@uta.fi
FAU - Lumia, Mirka
AU  - Lumia M
FAU - Kaila, Minna
AU  - Kaila M
FAU - Luukkainen, Paivi
AU  - Luukkainen P
FAU - Tapanainen, Heli
AU  - Tapanainen H
FAU - Erkkola, Maijaliisa
AU  - Erkkola M
FAU - Ahonen, Suvi
AU  - Ahonen S
FAU - Pekkanen, Juha
AU  - Pekkanen J
FAU - Klaukka, Timo
AU  - Klaukka T
FAU - Veijola, Riitta
AU  - Veijola R
FAU - Simell, Olli
AU  - Simell O
FAU - Knip, Mikael
AU  - Knip M
FAU - Virtanen, Suvi Mirjami
AU  - Virtanen SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100901
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
RN  - 0 (Anti-Asthmatic Agents)
SB  - IM
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Asthma/diagnosis/drug therapy/*epidemiology
MH  - Child, Preschool
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Insurance, Health, Reimbursement/*statistics & numerical data
MH  - Male
MH  - Prevalence
MH  - *Surveys and Questionnaires
EDAT- 2011/08/02 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.1111/j.1752-699X.2010.00222.x [doi]
PST - ppublish
SO  - Clin Respir J. 2011 Oct;5(4):211-8. doi: 10.1111/j.1752-699X.2010.00222.x. Epub 
      2010 Sep 1.