PMID- 21801705
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20120109
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Jan
TI  - The complex relationship between human herpesvirus 6 and acute graft-versus-host 
      disease.
PG  - 141-4
LID - 10.1016/j.bbmt.2011.07.018 [doi]
AB  - The most frequent manifestation of human herpesvirus 6 (HHV-6) reactivation after 
      allogeneic hematopoietic stem cell transplantation (HSCT) is febrile rash, 
      raising the question of its relationship with graft-versus-host disease (GVHD). 
      In this retrospective analysis of 365 patients who underwent allogeneic HSCT, 
      HHV-6 reactivation was significantly associated with cord blood transplantation 
      (hazard ratio [HR], 3.20; P < .0001) and the use of unrelated donors (HR, 2.02; P 
      = .008). On multivariate analysis, previous GVHD was a predictive factor for 
      HHV-6 reactivation (HR, 1.80; P = .01), and previous HHV-6 reactivation was a 
      predictive factor for acute GVHD (HR, 1.66; P = .03). Nineteen patients with no 
      pathological evidence of GVHD later developed severe clinical GVHD (grade 
      III-IV), suggesting the role of HHV-6 as a trigger for severe GVHD. Furthermore, 
      17 patients without histopathological GVHD demonstrated a significant lymphoid 
      infiltrate suggesting "pure" HHV-6-related manifestations, and these patients 
      could have been spared steroid therapy.
CI  - Copyright (c) 2012 American Society for Blood and Marrow Transplantation. Published 
      by Elsevier Inc. All rights reserved.
FAU - Pichereau, Claire
AU  - Pichereau C
AD  - Hematology/Transplantation, Service d'Hematologie Greffe, AP-HP, Hopital 
      Saint-Louis, Paris, France.
FAU - Desseaux, Kristell
AU  - Desseaux K
FAU - Janin, Anne
AU  - Janin A
FAU - Scieux, Catherine
AU  - Scieux C
FAU - Peffault de Latour, Regis
AU  - Peffault de Latour R
FAU - Xhaard, Alienor
AU  - Xhaard A
FAU - Robin, Marie
AU  - Robin M
FAU - Ribaud, Patricia
AU  - Ribaud P
FAU - Agbalika, Felix
AU  - Agbalika F
FAU - Chevret, Sylvie
AU  - Chevret S
FAU - Socie, Gerard
AU  - Socie G
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Graft vs Host Disease/immunology/*virology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Roseolovirus Infections/*immunology
MH  - Virus Activation/immunology
MH  - Young Adult
EDAT- 2011/08/02 06:00
MHDA- 2012/08/04 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/05/05 00:00 [received]
PHST- 2011/07/21 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
AID - S1083-8791(11)00308-9 [pii]
AID - 10.1016/j.bbmt.2011.07.018 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2012 Jan;18(1):141-4. doi: 
      10.1016/j.bbmt.2011.07.018. Epub 2011 Jul 27.