PMID- 21803340
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20110822
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1411
DP  - 2011 Sep 9
TI  - Auditory repetition enhancement at short interstimulus intervals for 
      frequency-modulated tones.
PG  - 65-75
LID - 10.1016/j.brainres.2011.07.009 [doi]
AB  - Frequency-modulated (FM) sweeps are important components of most natural sounds. 
      To examine the processing of these stimuli we applied a two-tone paradigm. 
      Repeated stimulus presentation usually leads to reduced neuronal responses. 
      However, in a former study repetition enhancements which have been observed when 
      FM tones were separated by short interstimulus intervals (ISIs) of </=200ms. To 
      further investigate this repetition effect in response to FM tones, we recorded 
      magnetoencephalogram (MEG) in humans during the presentation of consecutive FM 
      sweep pairs separated by ISIs between 100 and 600ms. We presented FM sweep pairs 
      in six experimental conditions: a) two upward FM tones, b) two downward FM tones, 
      c) an upward followed by a downward FM tone and d) a downward followed by an 
      upward FM tone. Sequences of single upward and single downward FM tones served as 
      control conditions. N1m amplitude was enhanced for repeated compared with 
      different FM-direction tone pairs. This effect was found for the shortest ISI of 
      100ms and disappeared at longer ISIs. Furthermore, mean peak latencies in 
      response to the second tone were prolonged in same-direction pairs at the 
      shortest ISI of 100ms. At ISIs >/=300ms slight enhancement effects occurred between 
      180 and 400ms after the second stimulus. This is in accordance with a previous 
      MEG study from our laboratory which demonstrated an enhancement effect for 
      sustained fields at latencies of 150-350ms after the second stimulus for same 
      compared to different FM tone pairs separated by an ISI of 200ms.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Heinemann, Linda V
AU  - Heinemann LV
AD  - Institute of Medical Psychology, Goethe University, Frankfurt am Main, Germany. 
      heinemann@med.uni-frankfurt.de
FAU - Kaiser, Jochen
AU  - Kaiser J
FAU - Altmann, Christian F
AU  - Altmann CF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110712
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - *Acoustic Stimulation
MH  - Adaptation, Psychological/physiology
MH  - Adult
MH  - Auditory Cortex
MH  - Auditory Perception/*physiology
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Magnetoencephalography
MH  - Male
MH  - Reaction Time/physiology
MH  - Young Adult
EDAT- 2011/08/02 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/07/05 00:00 [revised]
PHST- 2011/07/06 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - S0006-8993(11)01267-4 [pii]
AID - 10.1016/j.brainres.2011.07.009 [doi]
PST - ppublish
SO  - Brain Res. 2011 Sep 9;1411:65-75. doi: 10.1016/j.brainres.2011.07.009. Epub 2011 
      Jul 12.