PMID- 21805829
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20131121
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 9
DP  - 2011 May
TI  - [Evaluation of efficacy of esomeprazole treatment in patients with 
      laryngopharyngeal reflux].
PG  - 388-91
AB  - OBJECTIVE: To evaluate the efficacy of proton pump inhibitor (PPI) therapy with 
      esomeprazole on laryngopharyngeal reflux (LPR) by pepsin immunoassay in the 
      sputum. METHOD: From June 2009 to March 2010, patients in the ENT outpatient 
      department of Nanfang hospital with a reflux finding score (RFS) >7 and a reflux 
      symptom index (RSI) >13 were selected. Their sputum was obtained in the morning 
      for pepsin assay. Twenty-six patients with positive results of pepsin assay were 
      enrolled and received esomeprazole 20 mg twice daily for two months. They paid 
      return visits every two weeks. RSI, RFS and pepsin concentration in the sputum 
      were assessed at baseline and after two months. Pepsin in the sputum was measured 
      by enzyme linked immunoadsorbent assay. RESULT: After 8 weeks, 24 patients got 
      symptom improvements except 2. All got improved results of laryngoscope exams. 
      RSI and RFS scores before and after PPI treatment reached statistical 
      signification by paired t-test (t= 8.152, P<0.01; t=9.704, P<0.01). 21 patients' 
      pepsin concentrations decreased except 5. Nonparametric tests were used because 
      the reduction of pepsin concentrations before and after PPI treatment were not 
      normally distributed (Z=-3.213, P<0.01). Reductions of total RSI and RFS scores 
      as well as pepsin concentrations were significantly higher after two months. 
      CONCLUSION: Twice-daily PPI treatment for two months demonstrated a significantly 
      greater improvement in laryngeal appearance and LPR symptoms for most patients in 
      this study, which can result in significantly decreased levels of pepsin in 
      sputum.
FAU - Li, Xiangping
AU  - Li X
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Nanfang Hospital of 
      Southern Medical University, Guangzhou, 510515, China. lpl33402@yahoo.com.cn
FAU - Wu, Ting
AU  - Wu T
FAU - Wang, Lu
AU  - Wang L
FAU - Liu, Xiong
AU  - Liu X
FAU - Zeng, Fangfang
AU  - Zeng F
LA  - chi
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Proton Pump Inhibitors)
RN  - EC 3.4.23.1 (Pepsin A)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Esomeprazole/*therapeutic use
MH  - Female
MH  - Humans
MH  - Laryngopharyngeal Reflux/*drug therapy/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pepsin A/metabolism
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Sputum/chemistry
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/08/03 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 May;25(9):388-91.